Observational studyPloS one2026
Association of serum irisin levels with postoperative cognitive dysfunction in older patients following total hip or knee arthroplasty: A prospective observational study.
Observational study in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Current status and influencing factors of early delayed neurocognitive recovery in older adult patients after major orthopedic surgery under general anesthesia: a cohort study.Frontiers in public health · 2026Observational
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative cognitive dysfunction (POCD) is a frequent complication in older patients undergoing hip and knee arthroplasty. While irisin has demonstrated benefits in neurological disorders associated with cognitive impairment, its role in POCD remains unclear. This study investigated the association between serum irisin levels and POCD and assessed the discriminative value of irisin for POCD development.
methodsThis prospective observational study employed Spearman correlation and multifactorial logistic regression analyses to investigate the relationships between these biomarkers and POCD. Receiver operating characteristic analyses were then performed to assess the discriminative value of irisin.
resultPOCD occurred in 37 (31.36%) patients. Serum irisin levels were markedly reduced in patients with POCD relative to those without POCD. T0 irisin (rho = 0.675) levels correlated positively with Montreal cognitive assessment-Basic (MoCA-B) scores. Logistic regression analysis identified T0 irisin, T1 irisin, T0 Tumor necrosis factor-α (TNF-α), and hypertension as independent factors associated with the development of POCD (all P < 0.05). T0 irisin showed significant discriminative value for POCD, with a cutoff value of 302.840 ng/mL (Area Under the Curve [AUC]: 0.817; sensitivity: 0.757; specificity: 0.765).
conclusionIrisin may serve as an early warning biomarker for POCD, offering new insights for its prevention and treatment.
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