Evidence map›Paper›PMID 41961665›Full record

ArticleMedicine2026

Contrast-enhanced ultrasound-guided liver biopsy with flow cytometry analysis for the diagnosis of secondary hemophagocytic syndrome: A case report.

Huihui Ma, Qing Pan, Xin Jin, Shuyuan Tian

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Huihui MaCollege of Integrated Traditional Chinese and Western Clinical Medicine, Tongde Hospital of Zhejiang Province Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Qing PanDepartment of Pathology, Tongde Hospital of Zhejiang Province Afflicted to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Xin JinDepartment of Clinical Laboratory, Tongde Hospital of Zhejiang Province Afflicted to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Shuyuan TianDepartment of Ultrasound, Tongde Hospital of Zhejiang Province Afflicted to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.ORCID 0000-0001-5148-3733

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleHemophagocytic lymphohistiocytosis (HLH) is a hereditary or acquired hyperinflammatory response syndrome. Diagnosis of HLH is challenging. PATIENT CONCERNS: We report a case of a 41-year-old male who was admitted to the hospital due to recurrent fever for 1 month and hematochezia for 2 days. DIAGNOSES: Positron emission tomography/computed tomography (PET/CT) showed multiple intrahepatic high-uptake nodules, and B-mode ultrasound could not accurately localize them. Contrast-enhanced ultrasound (CEUS)-guided liver biopsy combined with flow cytometry confirmed the final diagnosis of natural killer (NK)/T-cell lymphoma-associated hemophagocytic syndrome. Pathological confirmation was made with a lymph node biopsy.

interventionsThe patient received the gemcitabine-dexamethasone-cisplatin (GDP) regimen and symptomatic supportive treatments. OUTCOMES: Unfortunately, the patient experienced persistent disease progression and passed away. LESSONS: HLH is a hyperinflammatory response syndrome caused by immune dysfunction. Lymphoma-associated hemophagocytic syndrome is the most common type of HLH. Diagnosis can be confirmed through CEUS-guided biopsy, flow cytometry analysis, and relevant clinical information.

Indexed as

Flow CytometryImage-Guided BiopsyLiverLymphohistiocytosis, HemophagocyticAdultContrast MediaFatal OutcomeHumansMalePositron Emission Tomography Computed TomographyUltrasonographyContrast Mediacontrastenhanced ultrasoundflow cytometryguided liver biopsysecondary hemophagocytic syndrome

Identifiers

PMID41961665
PMCPMC13593109

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.