ArticleMedicine2026
Diabetes, obesity, hyperlipidemia, and sudden sensorineural hearing loss: A bidirectional and multivariable Mendelian randomization study.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Many compelling observational studies suggest a reasonable correlation between diabetes, obesity, hyperlipidemia, and susceptibility to sudden sensorineural hearing loss (SSNHL). Nevertheless, some studies have observed results that are entirely opposite to this. We conducted a bidirectional and multivariable Mendelian randomization (MR) analysis to determine whether those associations are causal. Independent genetic variants associated with diabetes, obesity, hyperlipidemia, and SSNHL at the genome-wide significance level were selected as instrumental variables. All summary data can be obtained from the genome-wide association study database. The primary method utilized in the MR analysis was the inverse variance weighted method, while sensitivity analyses employed the weighted median method, MR-Egger method, and MR-PRESSO method. The MR analysis conducted using the inverse variance weighted method reveals a potential causal link between type 2 diabetes and the risk of SSNHL (odds ratio = 1.18, 95% confidence interval = 1.02-1.36, P = .03). These findings remain consistent in multivariate MR analysis, even after adjusting for obesity and hyperlipidemia (odds ratio = 1.17, 95% confidence interval = 1.01-1.36, P = .03). However, there is no discernible genetic evidence supporting a direct causal link between type 1 diabetes, obesity, and hyperlipidemia and the occurrence of SSNHL. Our bidirectional and multivariable MR analysis indicates that type 2 diabetes is a potential risk factor for SSNHL. Meanwhile, no direct causal relationship is identified between type 1 diabetes, obesity, hyperlipidemia, and the risk of SSNHL.
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