ReviewMedicine2026
The diagnostic and therapeutic challenges of pulmonary epithelioid trophoblastic tumor: A case report and literature review.
Review in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationalePrimary pulmonary epithelioid trophoblastic tumor (ETT) without a uterine primary is exceptionally rare, with merely 29 cases documented in the English-language literature. Therefore, a standardized management protocol has yet to be established, and the optimal treatment strategy remains poorly defined. PATIENT CONCERNS: A 31-year-old woman presented to a local hospital with irregular vaginal bleeding and was initially diagnosed with an ectopic pregnancy due to elevated serum beta-human chorionic gonadotropin (β-hCG) levels. Following treatment with diagnostic curettage and methotrexate, her β-hCG levels plateaued. The patient was subsequently referred to our institution for further investigation. Imaging revealed a 1.7 cm × 1.5 cm pulmonary nodule, which was initially suspected to be peripheral lung cancer. DIAGNOSES: Video-assisted thoracoscopic resection and subsequent histopathological analysis confirmed the diagnosis of ETT.
interventionsThe patient received 4 cycles of combined EMA/EP (etoposide, methotrexate, actinomycin D/etoposide, cisplatin) chemotherapy after the surgery. OUTCOMES: During 3 years of follow-up, her menstrual cycles were normal and there was no evidence of disease recurrence. LESSONS: This case highlights the diagnostic challenges and management strategies for pulmonary ETT, particularly in preserving fertility while ensuring optimal oncological outcomes.
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