Evidence map›Paper›PMID 41961592›Full record

ArticleCell reports2026

Naturally self-reactive B cells are poised to cross the selection barrier into autoimmune germinal centers.

Danni Yi-Dan Zhu, Maya Sangesland, Vintus Okonkwo, Zhenrui Zhang, Victoria Rosado, Larance Ronsard, Caitlin McCarthy, Caroline Alexander, Ralston M Barnes, Daniel Rohrer and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Danni Yi-Dan ZhuProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; PhD Program in Virology, Harvard Medical School, Boston, MA, USA.
Maya SangeslandRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA.
Vintus OkonkwoRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA.
Zhenrui ZhangProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; PhD Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.
Victoria RosadoRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA.
Larance RonsardRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA.
Caitlin McCarthyRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA.
Caroline AlexanderRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA.
Ralston M BarnesBristol-Myers Squibb, Redwood City, CA, USA.
Daniel RohrerBristol-Myers Squibb, Redwood City, CA, USA.
Nils LonbergBristol-Myers Squibb, Redwood City, CA, USA.
Debashree TagoreLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Musie GhebremichaelRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA; MGH Biostatistics, Boston, MA, USA.
Carlos CastrillonDepartment of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Joshua M AkeyLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Michael C CarrollProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. Electronic address: michael.carroll@childrens.harvard.edu.
Daniel LingwoodRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA. Electronic address: dlingwood@mgh.harvard.edu.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
Evolution of autoreactive GC and epitope spreading in lupusR01AR074105 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI Michael Craig Carroll · 2018 to 2026
$4.2M
FDC regulation of self-reactive B cellsR01AI130307 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CARROLL, MICHAEL CRAIG · 2018 to 2022
$2.7M
Identification and interpretation of introgressed hominin DNA in modern human genomesR01GM110068 · NIGMS · UNIVERSITY OF WASHINGTON · PI AKEY, JOSHUA MICHAEL · 2014 to 2024
$2.6M
Triggering germline-encoded broadly neutralizing antibody responses against influenza virusR01AI153098 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BATISTA, FACUNDO DAMIAN, LINGWOOD, DANIEL · 2020 to 2023
$2.1M
Systemic coordination of pro-inflammatory immune reactions through dendritic cell-restricted sIL6R biogenesisR01AI155447 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LINGWOOD, DANIEL · 2021 to 2025
$2.0M
Elicitation of pan-influenza A antibodies via simple B cell development pathwaysR01AI195539 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Facundo Damian Batista, Daniel Lingwood · 2026 to 2026
$661k
Sex differences in a cytokine controlling antibody class switch recombinationR21AI193280 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LINGWOOD, DANIEL · 2025 to 2025
$439k
NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI130307NIAID NIH HHS R01 AI153098NIAID NIH HHS R01 AI155447NIAID NIH HHS R01 AI195539NIAID NIH HHS R21 AI193280NIAMS NIH HHS R01 AR074105NIGMS NIH HHS R01 GM110068
6 · The paper itself

Abstract

Roughly 20% of circulating B cells react with self-antigens. An open question is whether germline autoreactivities expand when immune tolerance is breached. To test this, we supplied the 564Igi mouse model of spontaneous autoreactive germinal centers (GCs) with naive B cells that were polyclonal with human-like CDRH3 diversity but were genetically constrained to one of two alleles of the human antibody V

Indexed as

activationautoimmunityautoreactivityB cellCP: immunologygermline

Identifiers

PMID41961592
PMCPMC13188218

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.