ArticleCell reports2026
The atypical adhesion GPCR ADGRA1 controls hippocampal inhibitory circuit function.
Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Adhesion G-Protein Coupled Receptors in Neurological and Psychiatric Disorders.Journal of psychiatry and brain science · 2025Article
Corrections and comments
- Update of
Authors and funding
6 authors.
Funding
Abstract
Neural circuits contain a diverse array of inhibitory interneurons that control information processing. The cell surface receptors and signaling pathways that modulate cell-type-specific inhibitory function are unclear. Here, we identify the orphan G protein-coupled receptor (GPCR) ADGRA1 as essential for hippocampal PV inhibitory synaptic function. ADGRA1 is selectively enriched in hippocampal PV interneurons and localizes to a subset of synapses. ADGRA1 deletion in PV interneurons impairs intrinsic excitability and reduces inhibitory synaptic strength onto dentate gyrus granule cells. ADGRA1 engages several downstream G proteins, notably Gα13, a pathway important for the establishment of hippocampal PV interneuron synaptic networks. These results identify an orphan receptor pathway selective for fast-spiking PV neuron function and expand our understanding of the signaling mechanisms that establish hippocampal inhibitory circuits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.