Evidence map›Paper›PMID 41961523›Full record

ArticleJournal of synchrotron radiation2026

A pipeline for megahertz X-ray photon correlation spectroscopy on soft matter samples at the MID instrument of European XFEL.

Aliaksandr Leonau, Felix Brausse, James Wrigley, Mads B Jakobsen, Trey Guest, Amir Tosson, Michelle Dargasz, Nimmi Das Anthuparambil, Felix Lehmkühler, Anita Girelli and 21 more

Abstract read
In one paragraph

Article in Journal of synchrotron radiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Lipoprotein diffusion in dense yolk plasma is governed by softness, hydrodynamics, and caging: Insights from MHz-XPCS.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Aliaksandr LeonauEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID 0000-0002-4830-6856
Felix BrausseEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.
James WrigleyEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.
Mads B JakobsenEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID 0000-0003-0421-5343
Trey GuestEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.
Amir TossonDepartment Physik, Universität Siegen, Walter-Flex-Strasse 3, 57072 Siegen, Germany.ORCID 0000-0001-8291-6757
Michelle DargaszDepartment Physik, Universität Siegen, Walter-Flex-Strasse 3, 57072 Siegen, Germany.ORCID 0009-0008-1925-9860
Nimmi Das AnthuparambilDepartment Physik, Universität Siegen, Walter-Flex-Strasse 3, 57072 Siegen, Germany.ORCID 0000-0001-5338-2004
Felix LehmkühlerDeutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607 Hamburg, Germany.ORCID 0000-0003-1289-995X
Anita GirelliDepartment of Physics, AlbaNova University Center, Stockholm University, S-106 91 Stockholm, Sweden.
Maddalena BinDepartment of Physics, AlbaNova University Center, Stockholm University, S-106 91 Stockholm, Sweden.ORCID 0000-0003-4906-9335
Fivos PerakisDepartment of Physics, AlbaNova University Center, Stockholm University, S-106 91 Stockholm, Sweden.ORCID 0000-0001-9863-9811
Sebastian RetzbachInstitut für Angewandte Physik, Universität Tübingen, Auf der Morgenstelle 10, 72076 Tübingen, Germany.
Fajun ZhangInstitut für Angewandte Physik, Universität Tübingen, Auf der Morgenstelle 10, 72076 Tübingen, Germany.ORCID 0000-0001-7639-8594
Frank SchreiberInstitut für Angewandte Physik, Universität Tübingen, Auf der Morgenstelle 10, 72076 Tübingen, Germany.ORCID 0000-0003-3659-6718
Matheus TeodoroEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.
Cammille CarinanEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.
Robert RoscaEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.
Fabio Dall'AntoniaEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID 0000-0003-0799-2244
Wonhyuk JoEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID 0000-0002-7437-6129
Ulrike BoesenbergEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.
Angel Rodriguez-FernandezEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID 0000-0003-0587-5263
Roman ShaydukEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.
Jörg HallmannEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID 0000-0002-1996-397X
Alexey ZozulyaEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID 0000-0003-1048-3432
Jan Etienne PudellEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID 0000-0001-8268-444X
Carsten DeiterEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID 0000-0003-0268-6256
Luca GelisioEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID 0000-0001-7832-6201
Johannes MöllerEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID 0000-0001-8363-9077
Anders MadsenEuropean X-Ray Free-Electron Laser Facility, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID 0000-0001-6594-1029
Christian GuttDepartment Physik, Universität Siegen, Walter-Flex-Strasse 3, 57072 Siegen, Germany.ORCID 0000-0002-0051-8542

Funding

German National Research Data Infrastructure (NFDI) 460248799
6 · The paper itself

Abstract

In this article, we present the experimental protocol and data-processing framework for megahertz X-ray Photon Correlation Spectroscopy (MHz-XPCS) experiments on soft matter samples implemented at the Materials Imaging and Dynamics (MID) instrument of the European X-ray Free-Electron Laser (EuXFEL). Due to the introduction of a standard configuration and the implementation of a highly automated data-processing pipeline, MHz-XPCS measurements can now be conducted and analyzed with minimal user intervention. A key challenge lies in managing the extremely large data volumes generated by the Adaptive Gain Integrating Pixel Detector (AGIPD) - often reaching several petabytes within a single experiment. We describe the technical implementation, discuss the hardware requirements related to effective parallel data processing and propose strategies to enhance data quality, in particular related to data reduction strategies and an improvement of the signal-to-noise ratio. Finally, we address strategies for making the processed data FAIR (Findable, Accessible, Interoperable, Reusable), in alignment with the goals of the DAPHNE4NFDI project.

Indexed as

dynamicsmaterials imaging and dynamics (MID)MHz X-ray photon correlation spectroscopySAXSsoft matterXFEL

Identifiers

PMID41961523
PMCPMC13148601

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.