Evidence map›Paper›PMID 41961512›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Biomimetic Lubricant Captures Hyaluronic Acid In Situ to Regenerate Cartilage: From Bench to Bedside.

Yongan Lin, Zijian Yan, Jiayi Chen, Xiaochao Wang, Ruibin Lin, Yunqi Fu, Zhaoying Lv, Bohui Wu, Xuewei Cao, Renjian Xie and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yongan LinSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
Zijian YanSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
Jiayi ChenZhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan, China.
Xiaochao WangOrthopaedic Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China.
Ruibin LinSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
Yunqi FuSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
Zhaoying LvZhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan, China.
Bohui WuZhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan, China.
Xuewei CaoOrthopaedic Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China.
Renjian XieSchool of Medical Information Engineering, Gannan Medical University, Ganzhou, China.
Ming DongGuangzhou National Laboratory, Guangzhou International BioIsland, Guangzhou, China.
Chenxiao ZhengZhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan, China.
Li RenSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, China.ORCID 0000-0003-0604-9166

Funding

Guangdong Basic and Applied Basic Research Fund 2022B1515230008Guangdong Province Key Field R&D Program Projects 2020B1111150002Guangdong Province Key Field R&D Program Projects 202206010160Jiangxi Province Thousand Talents Project jxsq2023101065Jiangxi Provincial Natural Science Foundation 20252BAC220026Major Project of Guangzhou National Laboratory GZNL2024A03006National Natural Science Foundation of China 52173123National Natural Science Foundation of China 52303180
6 · The paper itself

Abstract

Lubrication deficiency can lead to cartilage degeneration and osteoarthritis (OA), for which hyaluronic acid (HA) is limited by its short retention and reparative effect. Inspired by the natural cartilage lubrication mechanism, we propose a two-step injection strategy to construct a biomimetic synergistic lubrication coating in situ on cartilage surfaces. The administration of developed cationic biomimetic lubricant (CS-g-PM) as the first injection to capture the subsequently administered HA via in situ self-assembly on the cartilage surface, forming a natural cartilage-like lubrication layer. In vitro, this strategy reduced friction coefficients to normal cartilage levels in OA human cartilage. Moreover, sequential CS-g-PM and HA articular-injection in OA rats extended HA retention 5-fold versus HA alone; meanwhile, regeneration of cartilage was synergistically promoted. Importantly, a first-in-human pretrial demonstrated rapid MRI-evident cartilage repair at 1 month. At 6 months of follow-up, patients showed sustained functional improvement and halted structural degeneration. This strategy offers a transformative solution for OA treatment.

Indexed as

Biomimetic MaterialsBiomimeticsCartilage, ArticularHyaluronic AcidLubricantsOsteoarthritisRegenerationAnimalsHumansInjections, Intra-ArticularRatsHyaluronic AcidLubricantsfirst‐in‐human pretrialhyaluronic acidosteoarthritisself‐assemblytwo‐step injection

Identifiers

PMID41961512
PMCPMC13334645

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.