Evidence map›Paper›PMID 41961434›Full record

ReviewCurrent pain and headache reports2026

Cognitive Dysfunction in Migraine: Underlying Mechanisms and Clinical Implications.

Ami Cuneo, Carrie E Robertson, Jennifer I Stern, Daniel Krashin, Aysha Siddika, Natalia Murinova

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pain and headache reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ami CuneoDepartment of Neurology, Headache Clinic, University of Washington, 4225 Roosevelt Way NE, Seattle, WA, 98195, USA. amiza@uw.edu.
Carrie E RobertsonDepartment of Neurology, Mayo Clinic, Rochester, USA.
Jennifer I SternDepartment of Neurology, Mayo Clinic, Rochester, USA.
Daniel KrashinDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, 98195, USA.
Aysha SiddikaDepartment of Neurology, Cleveland Clinic Florida, Weston, USA.
Natalia MurinovaDepartment of Neurology, Headache Clinic, University of Washington, 4225 Roosevelt Way NE, Seattle, WA, 98195, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewCognitive dysfunction (CD) is a common and disabling, yet under-recognized, symptom of migraine. Difficulty with receptive and expressive language, attention, and memory are reported ictally, while memory-related deficits are common interictally. Furthermore, migraine-related comorbidities can contribute independently to CD. RECENT

findingsBoth subjective patient-reported and objective neuropsychological testing cognitive changes occur in migraine. The pathophysiology of CD in migraine involves altered subcortical activity affecting the hypothalamus, hippocampus, and thalamus, as well as changes in brain network connectivity and energy imbalances. Though some studies suggest benefit for acute and preventive migraine treatments in migraine-related CD, limited data exists. CD is an important aspect of migraine-related disability. Development of validated assessment tools and biomarkers for CD in migraine remains a priority to optimize patient-centered care. Management of migraine-related CD requires a multi-dimensional approach addressing both migraine and comorbidities that can contribute to cognitive symptoms.

Indexed as

Cognitive DysfunctionMigraine DisordersBrainHumansNeuropsychological TestsCognitive dysfunctionMigraineMigraine comorbiditiesMigraine pathophysiologyMigraine treatment

Identifiers

PMID41961434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.