Evidence map›Paper›PMID 41961431›Full record

ReviewWorld journal of microbiology & biotechnology2026

Production and functional applications of fructooligosaccharides and their core bioactive components.

Xueli Su, Yu Lin, Zhenglong Li, Wei Zeng, Xiaoqun Duan

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of microbiology & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xueli Su *College of Pharmacy, Guilin Medical University, 1 Zhiyuan Road, Guilin, Guangxi, 541199, China.
Yu Lin *College of Basic Medical Sciences, Guilin Medical University, 1 Zhiyuan Road, Guilin, Guangxi, 541199, China.
Zhenglong LiCollege of Laboratory Medicine and Biotechnology, Guilin Medical University, 1 Zhiyuan Road, Guilin, Guangxi, 541199, China.
Wei ZengCollege of Pharmacy, Guilin Medical University, 1 Zhiyuan Road, Guilin, Guangxi, 541199, China. 19144204979@163.com.
Xiaoqun DuanCollege of Pharmacy, Guilin Medical University, 1 Zhiyuan Road, Guilin, Guangxi, 541199, China. ztwh1990@126.com.

Funding

Middle-aged and Young Teachers' Basic Ability Promotion Project of Guangxi 2024KY0524National Natural Science Foundation of China 32560547Natural Science Foundation of Guangxi Zhuang Autonomous Region 2025GXNSFBA069222
6 · The paper itself

Abstract

Fructooligosaccharides (FOS) are widely recognized as functional prebiotics with diverse physiological activities, including modulation of the gut microbiota, anti-diabetic effects, enhancement of immune responses, and other health promoting functions. Based on their terminal residues, FOS can be classified into fructose-terminated fructooligosaccharides (Fn, n = 2 ~ 9) and glucose-terminated fructooligosaccharides (GFn, n = 2 ~ 8). Compared with Fn, GFn exhibit distinct advantages in terms of raw material availability, production processes, manufacturing costs, and application potential, and therefore have received more attention. Among GFn, kestoses (GF2), nystose (GF3), and fructosylnystose (GF4) represent the core bioactive components and display distinct physiological effects. This review critically summarizes the current advances in the production and purification techniques of GFn mixtures and their core components (GF2, GF3 and GF4), with particular emphasis on 1-kestose due to its superior efficacy in gut microbiota modulation, aiming to provide valuable insights to support future production, application and development.

Indexed as

OligosaccharidesPrebioticsGastrointestinal MicrobiomeHumansTrisaccharides1-kestosefructooligosaccharideOligosaccharidesPrebioticsTrisaccharides1-KestoseFructooligosaccharidesPhysiological functionsProductionPurificationStructure-function relationship

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.