ArticleJournal of fluorescence2026
β-galactosidase Dynamic Monitoring in Cellular Senescence Process with a Novel Activatable Fluorescence Probe.
Article in Journal of fluorescence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
β-Galactosidase (β-gal), a common enzyme involved in hydrolysis, serves as an essential indicator for cellular aging and initial-stage ovarian tumors. Elevated levels of β-gal activity are commonly recognized as a sign of cell aging processes. Creating accurate and swift techniques to track β-gal function is vital for timely cancer identification and scientific investigations. As such, establishing a reliable approach to measure β-gal activity within living organisms is imperative. In this work, we created a responsive near-infrared (NIR) sensor called Xmgal to identify and image β-gal activity in tumor cells in real time. The Xmgal sensor functions via a β-galactosidase-triggered enzymatic cleavage mechanism, in which removal of the galactosyl caging group restores the NIR-emissive fluorophore. The fluorescence response exhibits a linear correlation with β-gal activity from 0.1 to 2.0 U, and a low detection limit of 1.5 mU. We applied Xmgal to observe and image β-gal activity in SK-OV3 ovarian cancer cells from humans, along with 293T cells. The Xmgal fluorescent sensor exhibits exceptional responsiveness, an activation-based NIR glow, significant wavelength change, and strong resistance to light degradation in active biological environments, making it an effective tool for continuous monitoring of β-gal dynamics.
Indexed as
Identifiers
41961420What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.