ArticleJournal of pharmacokinetics and pharmacodynamics2026
Mitigating antibiotic resistance from missed doses.
Article in Journal of pharmacokinetics and pharmacodynamics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
Abstract
Medication nonadherence and antibiotic resistance are well-recognized threats to public health. In this paper, we use modeling and simulation to investigate how nonadherence affects the emergence of antibiotic resistance. Using a pharmacokinetic (PK) and pharmacodynamic (PD) model that tracks the stochastic bacteria population, we find that (a) missing just one or two doses may significantly increase the risk of resistance, and (b) this risk can be alleviated by taking double doses after missed doses. Furthermore, we quantify how such double dosing increases the antibiotic plasma concentration based on the antibiotic half-life and dosing schedule. Though the effects of missed doses depend on PKPD parameters, this study presents a framework to probe how adherence affects resistance for specific antibiotics. More generally, our results highlight the need to reexamine conventional recommendations for handling missed doses.
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Registered trials
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