Evidence map›Paper›PMID 41961336›Full record

ArticleBiogerontology2026

Salidroside ameliorates skin aging in male mice by promoting collagen regeneration via modulation of FOS and MMP9.

Zheng Wang, Xiaoyue Yan, Xiaofeng Li, Hongzheng Zhu, Yuan Wang, Xiaofeng Fan, Xinyu Lu, Xiaoman Li, Miao Yang, Chi Zhang and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Biogerontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zheng WangJiangsu Key Laboratory for Pharmacology and Safety Research of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Xiaoyue YanJiangsu Key Laboratory for Pharmacology and Safety Research of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Xiaofeng LiJiangsu Key Laboratory for Pharmacology and Safety Research of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Hongzheng ZhuJiangsu Key Laboratory for Pharmacology and Safety Research of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Yuan WangThe Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, 211113, China.
Xiaofeng FanJiangsu Key Laboratory for Pharmacology and Safety Research of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Xinyu LuJiangsu Key Laboratory for Pharmacology and Safety Research of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Xiaoman LiJiangsu Key Laboratory for Pharmacology and Safety Research of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Miao YangKey Laboratory of Biotoxin Analysis & Assessment for State Market Regulation, Nanjing Institute of Product Quality Inspection & Testing, Nanjing, 210019, China.
Chi ZhangKey Laboratory of Biotoxin Analysis & Assessment for State Market Regulation, Nanjing Institute of Product Quality Inspection & Testing, Nanjing, 210019, China.
Yuanyuan WuJiangsu Key Laboratory for Pharmacology and Safety Research of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China. ywu@njucm.edu.cn.ORCID http://orcid.org/0000-0001-6231-2315

Funding

Natural Science Foundation of the Jiangsu Higher Education Institutions of China 23KJA360003Science and Technology Plan Project of Jiangsu Provincial Administration for Market Regulation KJ2025015
6 · The paper itself

Abstract

Salidroside, a phenolic compound derived from Rhodiola rosea L., has been widely utilized in cosmetics and medicine for its anti-melanogenic properties. However, its role in collagen regeneration during skin aging remains unclear. In this study, we investigated the effects of salidroside on collagen synthesis and explored its underlying mechanisms in a murine model of skin aging. Administering salidroside (20, 40, and 80 mg/kg) orally for 28 days significantly increased dermal thickness, collagen volume, and the expression of collagen I and III in male mouse skin. Bioinformatic analysis of RNA-seq data from the GSE278079 dataset revealed enhanced neutrophil infiltration in aged skin, suggesting a role for inflammatory processes in skin aging. Furthermore, salidroside up-regulated the expression of the transcription factor FOS and down-regulated matrix metalloproteinase MMP9, both in vivo and in L929 fibroblasts. These changes correlated with reduced collagen degradation and enhanced fibroblast activity. Crucially, siRNA-mediated silencing of Fos in vitro partially diminished the salidroside-induced upregulation of collagen expression, substantiating a causal regulatory role for FOS in this process. Our results demonstrate that salidroside promotes collagen regeneration and mitigates skin aging, which is closely associated with the attenuation of neutrophil-mediated inflammation, alongside the upregulation of FOS and downregulation of MMP9. These findings highlight the therapeutic potential of salidroside in combating age-related skin changes.

Indexed as

CollagenGlucosidesMatrix Metalloproteinase 9PhenolsProto-Oncogene Proteins c-fosRegenerationSkin AgingAnimalsFibroblastsMaleMiceMice, Inbred C57BLSkinCollagenGlucosidesMatrix Metalloproteinase 9Mmp9 protein, mousePhenolsProto-Oncogene Proteins c-fosrhodiolosideCollagen ICollagen IIIFosMmp9Salidroside

Identifiers

PMID41961336

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.