Evidence map›Paper›PMID 41961288›Full record

ArticleNeuroradiology2026

Intra-arterial chemoperfusion for breast cancer brain metastases: safety and efficacy.

Hamzah Adwan, Leon V Stein, Sven Becker, Claus Rödel, Thomas J Vogl

Abstract read
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In one paragraph

Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hamzah AdwanClinic for Radiology and Nuclear Medicine, Goethe University, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. adwan.hamza97@gmail.com.
Leon V SteinClinic for Radiology and Nuclear Medicine, Goethe University, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Sven BeckerDepartment of Gynecology and Obstetrics, Goethe University, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Claus RödelDepartment of Radiotherapy and Oncology, Goethe University, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Thomas J VoglClinic for Radiology and Nuclear Medicine, Goethe University, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. t.vogl@em.uni-frankfurt.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study presents a retrospective analysis of palliative intra-arterial chemoperfusion (IAC) for patients with symptomatic breast cancer brain metastases (BCBM) aiming to investigate the safety and efficacy of the treatment.

methodsThirteen patients with BCBM were treated using a total of 64 IACs, averaging 4.9 per patient. Overall survival (OS) and progression-free survival (PFS) were calculated using the Kaplan-Meier method. Response to IAC was evaluated according to RECIST 1.1.

resultsThere were no treatment-related major complications. A total of three patients (3/11) developed progressive disease. Five (5/11) patients achieved stable disease, two (2/11) partial response, and one (1/11) complete response, resulting in a local tumor control rate of 73% (8/11). Two (2/13) patients could not be evaluated according to RECIST 1.1. The median OS time was 8.2 months (95% CI: 7.7-8.7), and the median PFS time was 7.9 months (95% CI: 0.0-16.3). The mean OS time was 14.5 months (95% CI: 3.4-25.6), and the mean PFS time was 10.6 months (95% CI: 2.6-18.6).

conclusionIAC can be applied as a safe method for palliative patients with BCBM. Further studies are necessary to definitively determine its efficacy.

Indexed as

Breast cancer brain metastasesComplicationsIntra-arterial chemoperfusionOverall survivalProgression-free survivalTumor response

Identifiers

PMID41961288

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.