ArticleEuropean journal of applied physiology2026
Cellular profile of hematopoietic stem cells mobilized by exercise versus G-CSF in healthy related donors.
Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeHematopoietic stem cell transplantation (HSCT) depends on effective HSC mobilization with granulocyte colony-stimulating factor (G-CSF), though some allogeneic donors experience severe side effects. This study compares G-CSF and acute maximal exercise for HSC collection and cellular composition in 10 healthy family donors, examining links to donor fitness and recipient outcomes.
methodsTen donors (3 females; 40.8 (18.3) years) and their recipients (n = 8; 3 females; 47.5 (18.5) years) were enrolled. Donors completed cardiopulmonary exercise testing with blood samples taken pre- and post-exercise and on apheresis day for flow cytometric analysis. Recipients were followed up on day ~ 30 post-transplant.
resultsExercise significantly increased circulating total CD34+ cells (1.76-fold (0.51), p = 0.002) and select progenitor subsets (CD34+CD45dim, 1.74-fold (0.56), p = 0.006; and CD34+CD38+CD133+, 1.60-fold (0.46), p = 0.013), while other subsets showed no significant change (p > 0.05). Compared with post-exercise, apheresis resulted in markedly higher concentrations of total CD34+ cells (20.7-fold (9.7), p < 0.001) and all measured subsets. The largest enrichments were observed in CD34+ CD38-CD133+ (52.7-fold (69.3) p = 0.005) and CD34+CD38+CD133+ (38.2-fold (17.0), p < 0.001) populations. HSC collection at apheresis contained a 186.1-fold (72.3) elevation of immature granulocytes (p < 0.001) compared to the acute exercise (1.5-fold (0.3)). The proportions of apoptotic CD34+ cells and their subpopulations were similar post-exercise to apheresis (p > 0.05). Donor CD34+CD38- cell number was significantly negatively associated with recipient engrafting CD34+CD45dimCD90+ cells/µl (r=-0.70, p = 0.05, n = 8).
conclusionExercise might complement pharmacological mobilization by enhancing key HSC subgroups, improving collection quality, and supporting transplantation success; future research should evaluate combined approaches and the role of CRF in donor suitability and recipient outcomes.
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