Evidence map›Paper›PMID 41961228›Full record

ArticleJapanese journal of ophthalmology2026

Paired-eye comparison of photocoagulation versus intravitreal bevacizumab for retinopathy of prematurity: long-term visual, refractive, and ocular biometric outcomes at corrected ages 1, 5, and 9 years.

Yoshimi Fukushima, Machi Takata, Akiteru Kawahara, Hideki Chuman, Nobuhisa Naoi, Yasuhiro Ikeda

Erratum issuedAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Japanese journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Yoshimi FukushimaDepartment of Ophthalmology, Faculty of Medicine, University of Miyazaki Hospital, 5200, Kihara, Kiyotake town, Miyazaki city, Miyazaki Pref., 889-1692, Japan. yofuku@med.miyazaki-u.ac.jp.
Machi TakataDepartment of Ophthalmology, Faculty of Medicine, University of Miyazaki Hospital, 5200, Kihara, Kiyotake town, Miyazaki city, Miyazaki Pref., 889-1692, Japan.
Akiteru KawaharaDepartment of Ophthalmology, Faculty of Medicine, University of Miyazaki Hospital, 5200, Kihara, Kiyotake town, Miyazaki city, Miyazaki Pref., 889-1692, Japan.
Hideki ChumanDepartment of Ophthalmology, Faculty of Medicine, University of Miyazaki Hospital, 5200, Kihara, Kiyotake town, Miyazaki city, Miyazaki Pref., 889-1692, Japan.
Nobuhisa NaoiDepartment of Ophthalmology, Faculty of Medicine, University of Miyazaki Hospital, 5200, Kihara, Kiyotake town, Miyazaki city, Miyazaki Pref., 889-1692, Japan.
Yasuhiro IkedaDepartment of Ophthalmology, Faculty of Medicine, University of Miyazaki Hospital, 5200, Kihara, Kiyotake town, Miyazaki city, Miyazaki Pref., 889-1692, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate long-term outcomes of photocoagulation (PC) and intravitreal bevacizumab (IVB) for retinopathy of prematurity (ROP). STUDY

designRetrospective paired-eye comparison.

methodsTwenty-one patients (42 eyes) treated for ROP between 2009-2010 were included. In each subject, one eye received PC and the fellow IVB. Visual acuity (VA), refraction (spherical equivalent [SE], cylinder power [CP], corneal astigmatism [CA]), and ocular biometry (corneal curvature radius, anterior chamber depth [ACD], lens thickness [LT], and axial length [AL]) were assessed at corrected ages of 1, 5, and 9 years. Cross-sectional differences were analyzed using the Wilcoxon signed-rank test, with Bonferroni correction applied at 9 years. Annual rates of change were evaluated using a linear mixed-effects model (LMM). Inter-treatment differences were assessed using Spearman correlation analysis.

resultsAt 9 years, PC-treated eyes showed significantly worse VA, greater myopia, and shorter AL (all p < 0.05). ACD was deeper in IVB-treated eyes, while CP and CA were greater in PC-treated eyes. LMM revealed a significantly faster progression of myopia and CP in PC-treated eyes. Conversely, the annual rates of ACD deepening and LT thinning were significantly faster in IVB-treated eyes, whereas no significant differences were observed for VA or AL. Inter-treatment differences in SE were significantly correlated with AL differences, whereas VA differences were correlated with ACD.

conclusionIVB-treated eyes showed better VA, less myopia, and more favorable refractive and biometric parameters. SE differences were associated with AL, whereas VA differences were associated with ACD, indicating distinct structural mechanisms.

Indexed as

BevacizumabLaser CoagulationRefraction, OcularRetinopathy of PrematurityVisual AcuityAngiogenesis InhibitorsBiometryChildChild, PreschoolCross-Sectional StudiesFemaleFollow-Up StudiesGestational AgeHumansInfantInfant, NewbornAngiogenesis InhibitorsBevacizumabVascular Endothelial Growth Factor AIntravitreal bevacizumabLaser photocoagulationLong-term outcomesPaired-eye comparisonRetinopathy of prematurity

Identifiers

PMID41961228

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.