ArticleClinical and experimental nephrology2026
Association between serum zinc and cognitive function in patients undergoing maintenance hemodialysis: the Osaka Dialysis Complication Study (ODCS).
Article in Clinical and experimental nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundZinc deficiency is highly prevalent in patients undergoing hemodialysis, and may contribute to cognitive impairment, given its essential role in neurotransmission and neurogenesis. This study aimed to examine the association between serum zinc and cognitive function in this population.
methodsThis was a cross-sectional study (N = 1207). Cognitive function was assessed by using the Modified Mini-Mental State examination (3MS). The association between serum zinc and 3MS score and its domains were examined by using a linear regression model and ordinal logistic regression model, respectively.
resultsIn total patients, 3MS score and serum zins levels were 91 (82-97) points and 68 (61-76) μg/dL, respectively. Serum zinc level was not associated with 3MS score in adjusted model with 16 potential confounders. However, there was a significant interaction between serum zinc and albumin levels (p = 0.019). Therefore, participants were categorized into 2 subgroups by the median serum albumin level (3.7 g/dL) in further analyses. In the lower serum albumin group, the positive association between serum zinc and 3MS was significant after adjustment for 15 potential confounders (p = 0.022). After additional adjustment for both magnesium and phosphate, the association showed a similar positive trend but did not reach statistical significance (p = 0.072). Among the cognitive domains of the 3MS, attention was significantly associated with serum zinc level in participants with lower serum albumin (p = 0.016).
conclusionsLower serum zinc was a novel factor associated with cognitive function, particularly in attention in patients undergoing maintenance hemodialysis with low serum albumin.
Indexed as
Identifiers
41961222What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.