Evidence map›Paper›PMID 41961199›Full record

ArticleMycopathologia2026

Emergence and Genomic Profiling of Multidrug-Resistant Candida auris Isolated from Intensive Care Unit Patients in a Malaysian Teaching Hospital.

Nishanthinie Thatchanamoorthy, Rukumani Devi Velayuthan, Chandramathi Samudi Raju, Subha Bhassu, Alexandria Sonia Karajacob, Sasheela Ponnampalavanar, Mohan Rao, Sun Tee Tay

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mycopathologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Journal of fungi (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nishanthinie ThatchanamoorthyDepartment of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Jalan Profesor Diraja Ungku Aziz, 50603, Kuala Lumpur, Wilayah Persekutuan, Malaysia.
Rukumani Devi VelayuthanDepartment of Medical Microbiology, Universiti Malaya Medical Centre, Jalan Profesor Diraja Ungku Aziz, 59100, Kuala Lumpur, Wilayah Persekutuan, Malaysia. rukumani@ummc.edu.my.
Chandramathi Samudi RajuDepartment of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Jalan Profesor Diraja Ungku Aziz, 50603, Kuala Lumpur, Wilayah Persekutuan, Malaysia.
Subha BhassuInstitute of Biological Sciences, Faculty of Science, Universiti Malaya, Jalan Profesor Diraja Ungku Aziz, 50603, Kuala Lumpur, Wilayah Persekutuan, Malaysia.
Alexandria Sonia KarajacobDepartment of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Jalan Profesor Diraja Ungku Aziz, 50603, Kuala Lumpur, Wilayah Persekutuan, Malaysia.
Sasheela PonnampalavanarDepartment of Medicine, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Federal Territory of Kuala Lumpur, Malaysia.
Mohan RaoDepartment of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Jalan Profesor Diraja Ungku Aziz, 50603, Kuala Lumpur, Wilayah Persekutuan, Malaysia.
Sun Tee TayDepartment of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Jalan Profesor Diraja Ungku Aziz, 50603, Kuala Lumpur, Wilayah Persekutuan, Malaysia. tayst@um.edu.my.

Funding

UMSC CA.R.E fund PV020-2020
6 · The paper itself

Abstract

Candida auris, a significant pathogen causing invasive candidiasis with high mortality rates and frequent hospital outbreaks, is understudied in Malaysia. This study retrospectively examined invasive candidiasis cases at Universiti Malaya Medical Centre from 2018 to 2021. Four C. auris strains were isolated from blood and peritoneal samples of intensive care unit patients and identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Antifungal susceptibility testing using Sensititre™ YeastOne YO10 plate showed resistance to amphotericin B (2-4 µg/ml) and fluconazole (256 µg/ml) but susceptibility to echinocandins. Whole-genome sequencing revealed a 12.31 Mb genome, 45.59% G + C content, 99.95-99.99% average nucleotide identity between the isolates, and 190-225 single nucleotide polymorphisms. The Malaysian strains were phylogenetically related to the South Asian Clade (I) and harbored mutations associated with resistance to fluconazole (ERG11 gene: Y132F; CDR1 gene: E709D) and amphotericin B (ERG2 gene: E39D). The first genomic characterization of multidrug-resistant C. auris in Malaysian ICU patients highlights the urgent need for enhanced infection control measures in healthcare settings.

Indexed as

Antifungal AgentsCandida aurisCandidiasis, InvasiveDrug Resistance, Multiple, FungalIntensive Care UnitsAmphotericin BFemaleFluconazoleGenome, FungalHospitals, TeachingHumansMalaysiaMaleMicrobial Sensitivity TestsMiddle AgedPhylogenyAmphotericin BAntifungal AgentsFluconazoleAntifungal resistanceCandida aurisMalaysiaWhole genome sequencing

Identifiers

PMID41961199
PMCPMC13068732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.