ArticleEchocardiography (Mount Kisco, N.Y.)2026
Calibrated Integrated Backscatter Is Associated With Increased Left Ventricular Concentricity and Left Atrial Stiffness in Resistance Trained Individuals Using Anabolic-Androgenic Steroids.
Article in Echocardiography (Mount Kisco, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThe use of Anabolic-Androgenic Steroids (AAS) is well documented in resistance trained individuals, despite reports of myocardial inflammation and fibrosis. Calibrated integrated backscatter (ciB) is an echocardiographic technique to measure ultrasonic reflectivity of the left ventricular (LV) myocardium and is a marker for tissue characterization. This study assessed ciB in both AAS using and non-using resistance trained individuals and documented any relationship to LV and left atrial (LA) structure and function.
methodsMale (n = 120) and female (n = 21) resistance trained individuals (age 30 ± 7 years); current (CU; n = 95) and non-users (NU; n = 46) of AAS were recruited. Comprehensive echocardiography with strain imaging was performed. ciB was measured from a parasternal long axis and LA stiffness index (E/E'/LA reservoir strain) and left atrioventricular coupling index (LA end-diastolic volume/LV end-diastolic volume) were calculated.
resultsciB was significantly higher in CU (-19.54 ± 4.63) than NU (-20.88 ± 3.94, p = 0.047). A significant positive correlation was observed between ciB and LV mass index (r
conclusionsResistance trained individuals using AAS have significantly higher ciB than non-users, suggesting differential myocardial tissue characteristics within this population. The presence of higher levels of ciB was significantly associated with LV geometry and LV diastolic function which may indicate a role of ciB in identifying early cardiac risk in this population.
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