ArticleMolecular pharmaceutics2026
Novel Gold-Functionalization of Liposomes and Its Impact on Cellular Uptake and Trafficking.
Article in Molecular pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liposomes decorated with gold nanoparticles (AuNPs) represent multifunctional nanocarriers that combine high drug-loading capacity with the unique physicochemical properties of metallic nanoparticles. Here, we report a simple one-pot strategy for the controlled surface attachment of citrate-stabilized AuNPs to liposomes, based on the synergistic action of electrostatic and covalent interactions. This was achieved by incorporating two functional lipids: the cationic lipid DOTAP, providing a permanent positive surface charge that promotes electrostatic attraction toward negatively charged AuNPs, and the thiol-containing lipid DPSH, possessing a functional group known for stable Au-S bond formation. Simple mixing of AuNPs with DOTAP&DPSH liposomes resulted in a hydrodynamic diameter increase corresponding approximately to twice the AuNP diameter, a reduction in ζ-potential, and a red shift of the AuNP plasmon absorption maximum, confirming nanoparticle attachment. Adsorption of AuNPs onto lipid monolayers was further verified electrochemically at the electrified liquid-liquid interface. Biological studies demonstrated that AuNP decoration significantly enhanced cellular uptake. The effect was most pronounced after 24 h of incubation at a lipid concentration of 40 μg·mL
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Registered trials
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