Diagnostic utility of salivary LDH and MMP-9 in differentiating oral cancer from potentially malignant disorders.

Ragini Motwani, Yash Saxena, Ipsita Sharma, Maheshwari Shanmugam, Nidhi Dhakar, Swati Sp, Tanvi Hirani

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Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Ragini MotwaniDepartment of Oral Pathology and Microbiology, Peoples Dental Academy, Bhopal, Madhya Pradesh, India.

Yash SaxenaDepartment of Pathology, Government Medical College, Satna, Madhya Pradesh, India.

Ipsita SharmaDepartment of Oral Pathology & Microbiology, RKDF Dental College & Research Centre, Bhopal, Madhya Pradesh, India.

Maheshwari ShanmugamDepartment of Oral Pathology and Microbiology, JKKN Dental College and Hospital, Komarapalayam, India.

Nidhi DhakarDepartment of Oral Pathology and Oral Microbiology, Government Dental College and Hospital, Ahmedabad, Gujarat, India.

Swati SpDepartment of Public Health Dentistry, MGM Dental College & Hospital, Kamothe, Maharashtra, India.

Tanvi HiraniDepartment of Periodontology and Implantology, Karnavati School of Dentistry, Karnavati University Gandhinagar, Gujarat, India.

Funding

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6 · The paper itself

Abstract

Early distinction between oral squamous cell carcinoma (OSCC) and possibly malignant disorders (PMDs) has been one of the most important diagnostic issues that may involve invasive biopsies. Therefore, it is of interest to assess the usefulness of salivary lactate dehydrogenase (LDH) and matrix metalloproteinase-9 (MMP-9) as non-invasive biomarkers of early detection. Spectrophotometry and ELISA were used in analyzing saliva samples of 135 participants (50 OSCC, 45 PMDs, 40 controls). The level of LDH and MMP-9 was much greater in OSCC than in PMDs and controls and demonstrated very high diagnostic accuracy (AUC > 0.89). Simultaneous biomarker measurement had better sensitivity and specificity indicating their possible use as well-grounded, non-invasive measures of screening oral cancer in its early stages.

Indexed as

early diagnosislactate dehydrogenasematrix metalloproteinase-9non-invasive diagnosticsOral squamous cell carcinomapotentially malignant disorderssalivary biomarkers

Identifiers

PMID41960521

DOI10.6026/973206300220230

PMCPMC13058287

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