ArticleBioinformation2026
Emerging trends in enamel remineralization.
Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The enamel of our teeth is heavily mineralized and undergoes repeated cycles of demineralization and remineralization. Despite long- term use of fluorides, ACP-CPP and bioactive glass as remineralizing agents, their limited properties prevent complete restoration of the enamel's hierarchical structure, leading to the introduction of biomimetic agents that mimic the natural formation of enamel while also exhibiting antibacterial effects. Biomimetic strategies include amelogenin-derived peptides, chitosan hydrogels and Poly (amidoamine) dendrimers (PAMAM). Nanotechnology integrates nano-hydroxyapatite and calcium salts into weakened enamel. At the same time, smart materials incorporate pH-responsive composites and ion-releasing sealants that target remineralization and exhibit antimicrobial effects under cariogenic conditions. While these approaches show promising results, their routine clinical adoption requires additional cost, scalability and regulatory challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.