Triamcinolone acetate and triamcinolone-isotretinoin efficacy in oral lichen planus management: Original clinical study.

Anish Ashok Gupta, Vatchala Rani R M, Prarthana G A, Vaibhavi Mehta, Monika Tanwar, Santosh Kumar

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Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Anish Ashok GuptaDepartment of Oral Pathology & Microbiology, People's Dental Academy, People's University, Bhopal, Madhya Pradesh, India.

Vatchala Rani R MDepartment of Oral pathology and Microbiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India.

Prarthana G ADepartment of Oral medicine and Radiology, Rajarajeswari Dental College and Hospital, Bangalore, Karnataka, India.

Vaibhavi MehtaDepartment of Oral Medicine and Radiology, K.M. Shah Dental College and Hospital, Sumandeep Vidhyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, India.

Monika TanwarDepartment of Oral and Maxillofacial Surgery, SGT University, Gurgaon, Haryana, India.

Santosh KumarDepartment of Periodontology & Implantology, Karnavati University, Uvarsad, Gandhinagar, Ahmedabad, Gujarat, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral lichen planus (OLP) is a long-term inflammatory mucocutaneous disease that has the potential of malignant transformation. Hence, it requires effective long-term therapy. It was a randomized controlled, double-blind trial comparing triamcinolone acetonide 0.1 per cent oral paste (TA) to TA once daily with oral isotretinoin 10mg daily (TA+ISO) in 70 cases (biopsy-established) of OLP of more than 12 weeks duration. The TA+ISO group showed better clinical outcomes as the means of Thongprasom scores reduced in the TA group (p<0.001). TA+ISO showed more pain reduction (VAS) at 12 weeks (p<0.001), improved Histopathological (74.3) TA+ISO (p=0.006) and reduced Lesion size (p<0.001). TA in combination with isotretinoin is very useful as combination therapy in OLP and clinical and histopathological results are improved.

Indexed as

combination therapyisotretinoinmalignant potentialOral lichen planusThongprasom scoretriamcinolone acetonide

Identifiers

PMID41960476

DOI10.6026/973206300220201

PMCPMC13058305

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