ArticleBioinformation2026
An update on articaine use in dentistry.
Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Articaine hydrochloride is considered a highly effective and reliable local anesthetic in dentistry owing to its unique pharmacological characteristics. Its thiophene ring and ester group enhance lipid solubility, ensuring rapid tissue diffusion and efficient hydrolysis that limit systemic toxicity. The 4% formulation offers quicker onset, extended pulpal and soft tissue anesthesia and superior bone penetration compared with lidocaine, mepivacaine, and prilocaine. Recent advancements such as buffered formulations, antibacterial modifications and needle-free systems have further broadened its potential applications. This contributes to high procedural efficiency, improved patient comfort and prolonged anesthetic effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.