Evidence map›Paper›PMID 41960437›Full record

ReviewFrontiers in microbiology2026

Unveiling the gut: microbiota and derived metabolites' role in the rising tide of precocious puberty.

Anqi Zhang, Xuesong Wang, Zhanzhao Wang, Lili Zhang, Xiaohe Zhu, Yuxin Zhu, Yongmei Liu, Chenglong Zhu, Donghua Xu, Honggang Wang and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anqi Zhang *Department of Medical Research Center, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
Xuesong Wang *Clinical Laboratory, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
Zhanzhao WangClinical Laboratory, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
Lili ZhangDepartment of Medical Research Center, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
Xiaohe ZhuDepartment of Obstetrics, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
Yuxin ZhuDepartment of Medical Research Center, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
Yongmei LiuDepartment of Medical Research Center, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
Chenglong ZhuShandong Laibo Biotechnology Co., Ltd., Jinan, China.
Donghua XuDepartment of Medical Research Center, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
Honggang WangClinical Laboratory, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
Lu ZhaoDepartment of Medical Research Center, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the rising global incidence of precocious puberty, understanding its pathogenesis is crucial. The gut microbiota, a key regulator of host physiology, has emerged as a potential contributor. While microbial alterations are observed during puberty and dysbiosis is associated with its early onset, definitive mechanisms are unclear. This review examines the role of gut microbiota and derived metabolites in precocious puberty through its effects on endocrine, immune, metabolic, and gut-brain axis. By integrating existing research, the purpose of this review is to provide a conceptual framework and highlight prospects for novel diagnostics and therapeutics.

Indexed as

endocrinegut-brain axisgut microbiotametabolitesprecocious puberty

Identifiers

PMID41960437
PMCPMC13057450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.