Evidence map›Paper›PMID 41960405›Full record

Observational studyFrontiers in public health2026

Subcutaneous application of

Jan Vagedes, Angelika Hagen, Mohammad Oli Al Islam, Mohsen Sobh, Katrin Vagedes, Henrik Szőke, Matthias Kohl, Johannes Wilkens

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jan VagedesARCIM Institute for Academic Research in Complementary and Integrative Medicine, Filderstadt, Germany.
Angelika HagenGeriatric Rehabilitation Center, Alexander von Humboldt Clinic, Bad Steben, Germany.
Mohammad Oli Al IslamARCIM Institute for Academic Research in Complementary and Integrative Medicine, Filderstadt, Germany.
Mohsen SobhARCIM Institute for Academic Research in Complementary and Integrative Medicine, Filderstadt, Germany.
Katrin VagedesARCIM Institute for Academic Research in Complementary and Integrative Medicine, Filderstadt, Germany.
Henrik SzőkeDepartment of Integrative Medicine, University of Pécs, Pécs, Hungary.
Matthias KohlInstitute of Precision Medicine, University Furtwangen, Villingen-Schwenningen, Germany.
Johannes WilkensGeriatric Rehabilitation Center, Alexander von Humboldt Clinic, Bad Steben, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Dementia is a neurodegenerative disease that affects more than 45 million patients worldwide. Treatment options for dementia include lecanemab for mild cognitive impairment, acetylcholinesterase inhibitors, which are mainly used for mild to moderate dementia, as well as N-methyl-D-aspartate receptor antagonists for patients with severe dementia or certain antipsychotics. Pharmaceutical approaches are limited by potential side effects. To alleviate symptoms or at least slightly improve cognitive functions, additional herbal medicines (HM) such as Methods: Retrospective study on the effect of subcutaneous application of Results: For the primary outcome, there was a statistically significant difference in MMSE between the groups ( Conclusion: The study gives preliminary evidence that Clinical trial registration: Identifier, DRKS00033972.

Indexed as

DementiaHelleborusPhytotherapyPlant ExtractsAgedAged, 80 and overFemaleGermanyHumansInjections, SubcutaneousMaleRetrospective StudiesPlant Extractscognitive impairmentcomplementary and integrative medicinedementiaHelleborus nigerinpatientsolder adults patientssubcutaneous applicationtraditional

Identifiers

PMID41960405
PMCPMC13057344

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.