Evidence map›Paper›PMID 41960277›Full record

ArticleDose-response : a publication of International Hormesis Society

Skeletal Stem Cells Rescue Radiation-Induced Osteogenic Precursor Cell Dysfunction via the Wnt/β-Catenin Signaling Pathway.

Huahui Bian, Dongyang Zhao, Haoyu Wang, Hao Huang, Youyou Wang, Weibo Chen, Chang Liu, Yinyin Yang, Anqing Wu, Yulong Liu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Huahui BianNuclear Emergency Medicine Department, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Dongyang ZhaoDepartment of Orthopedic, Suzhou Xiangcheng People's Hospital, Suzhou, China.
Haoyu WangDepartment of Rehabilitation, School of Medical Technology, Tianjin Medical University, Tianjin, China.
Hao HuangDepartment of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Youyou WangNuclear Emergency Medicine Department, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Weibo ChenNuclear Emergency Medicine Department, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Chang LiuClinical Diagnosis and Treatment Center of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Yinyin YangClinical Diagnosis and Treatment Center of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Anqing WuState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0002-9009-640X
Yulong LiuNuclear Emergency Medicine Department, The Second Affiliated Hospital of Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0003-2660-8076

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Skeletal stem cells (SSCs), a specialized subset of mesenchymal stem cells, drive bone regeneration. This study aimed to characterize the pathological effects of ionizing radiation (IR) on osteogenic precursor cells (MC3T3-E1) and to elucidate the therapeutic efficacy and underlying molecular mechanisms of SSC-mediated rescue. Methods: Experiments were performed using clonogenic assay, micronucleus assay, flow cytometry, osteogenic differentiation assessment, migration assay, and animal model establishment. Results: The results demonstrated that IR compromised the clonogenic capacity of MC3T3-E1 cells, exacerbated genomic damage, induced apoptosis, and significantly impaired their osteogenic differentiation and migratory potential. Conclusions: This study indicates that SSCs effectively alleviate IR-induced injury to osteoblast progenitor cells, providing compelling evidence and establishing a novel therapeutic paradigm for treating radiation-related skeletal complications.

Indexed as

bone regenerationirradiationosteogenic precursor cellsskeletal stem cellsWnt/β-catenin signaling

Identifiers

PMID41960277
PMCPMC13058216

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.