ReviewFrontiers in psychiatry2026
Animal models for the study of ADHD: the need for next-generation models.
Review in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Prenatal and Lactation Exposure to Bisphenol A (BPA) at the Global Mean Daily Intake Level Leads to Sex-Dependent Changes in Microglial State, Gene Expression, and Behavioral Patterns in Newborn and Juvenile Wistar Rat Offspring.Life (Basel, Switzerland) · 2026Article
- Comparative Proteomic Analysis of the Striatum in Heterozygous and Null DAT Knockout Rats.International journal of molecular sciences · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal models have long been indispensable for elucidating the pathophysiology of neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD). However, many existing models inadequately capture the full spectrum of ADHD symptoms and their underlying neurobiological mechanisms. In this Mini Review, we argue that continued reliance on simplistic genetic models limits mechanistic insight and that next-generation approaches must integrate gene-environment (G×E) frameworks, together with behavioral readouts informed by the triple-pathway model of ADHD. Such approaches are essential for interrogating pharmacoresistant domains of ADHD, including executive dysfunction and impaired time perception, which remain inadequately addressed by current pharmacotherapies.
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