Endoplasmic reticulum targeted photosensitizer with high photostability and dual ROS generation for breast cancer PDT via apoptosis and pyroptosis.

Wenzhao Shang, Cuiping Yang, Lulu Sun, Sufan Wang, Yifan Xu, Ben Zhong Tang, Huifang Su

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenzhao ShangDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, PR China.

Cuiping YangSchool of Chemistry and Chemical Engineering, Tarim University, Alar, Xinjiang, 843300, PR China.

Lulu SunDepartment of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, PR China.

Sufan WangHenan Key Laboratory of Chronic Disease Prevention and Therapy & Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, PR China.

Yifan XuDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, PR China.

Ben Zhong TangSchool of Science and Engineering, Guangdong Basic Research Center of Excellence for Aggregate Science, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong, 518172, PR China.

Huifang SuDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In tumor photodynamic therapy, the development of theranostic probes with favorable targeting capability, biocompatibility, and high photosensitizing activity is essential for enhancing therapeutic precision and efficacy. However, most existing probes are limited by insufficient targeting and an imbalance between phototoxicity and biosafety. In this study, we synthesized a biocompatible luminogen (compound 3), which can be applied to pH sensing,

Indexed as

Cell apoptosisCell pyroptosisEndoplasmic reticulum-targetedImmunogenic cell deathPhototherapyTwo-photon imaging

Identifiers

PMID41960156

DOI10.1016/j.mtbio.2026.103066

PMCPMC13059314

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.