Evidence map›Paper›PMID 41960123›Full record

ArticleJTCVS open2026

Minimally invasive mitral valve repair: Ten-year outcomes of the "Re-Lock technique" for complex bileaflet mitral valve disease.

Giuseppe Speziale, Raffaele Bonifazi, Tommaso Loizzo, Ernesto Greco, Giuseppe Nasso

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Article in JTCVS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Giuseppe SpezialeDepartment of Cardiac Surgery, Anthea Hospital and Santa Maria Hospital, GVM Care & Research, Bari, Italy.
Raffaele BonifaziDepartment of Cardiac Surgery, Anthea Hospital and Santa Maria Hospital, GVM Care & Research, Bari, Italy.
Tommaso LoizzoDepartment of Cardiac Surgery, Anthea Hospital and Santa Maria Hospital, GVM Care & Research, Bari, Italy.
Ernesto GrecoDepartment of Health and Life Sciences, European University of Rome, Rome, Italy.
Giuseppe NassoDepartment of Cardiac Surgery, Anthea Hospital and Santa Maria Hospital, GVM Care & Research, Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The objective was to evaluate the 10-year clinical and echocardiographic outcomes of minimally invasive Re-Lock mitral valve repair for Barlow-type or complex bileaflet degenerative disease, evaluating overall survival, freedom from mitral regurgitation 2+ or greater, need for reoperation, and New York Heart Associaton class. Methods: From 2008 to 2016, 140 consecutive patients with Barlow-type degenerative bileaflet mitral valve disease underwent video-assisted minimally invasive right anterolateral thoracotomy repair at a single institution. In all cases, the repair was based on the Re-Lock maneuver. Patients were classified according to the need for anterior intervention. Group 1 included patients receiving Re-Lock only (n = 33), in whom anterior billowing or mild prolapse became competent after posterior correction and required no additional repair. Group 2 included patients receiving Re-Lock + anterior expanded polytetrafluoroethylene neochordae (n = 107), in whom true anterior prolapse or flail warranted targeted neochordal implantation. Follow-up was completed through scheduled clinical and echocardiographic evaluations, with a median duration of 10.2 years. Results: Technical success with freedom of mitral regurgitation (mild or less on intraoperative transesophageal echocardiography) was 99.3%, with no 30-day mortality. At 10 years, overall survival was 95.7%. Freedom from mitral regurgitation 2+ or greater was 91.2%, and freedom from reoperation was 96.4%. Postoperative New York Heart Association class improved in 130 of 140 patients (92.9%) and maintained class I at last follow-up in 122 of 130 survivors (93.8%). No statistically significant difference was observed in outcomes by technique group (log-rank Conclusions: The minimally invasive Re-Lock technique provides safe, reproducible, and effective long-term results for complex bileaflet mitral valve disease, including Barlow's pathology.

Indexed as

mitral valve repairposterior leaflet prolapseRe-Lock technique

Identifiers

PMID41960123
PMCPMC13059993

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.