ArticleJTCVS open2026
Liver disease severity score predicts early and late mortality after lung transplantation: A United Network for Organ Sharing database analysis.
Article in JTCVS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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16 authors.
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Abstract
Objective: Hepatorenal dysfunction after lung transplantation is associated with significant morbidity and mortality. The Model for End-stage Liver Disease excluding international normalized ratio (MELD-XI) score may predict outcomes after lung transplantation. Methods: Adult lung transplant recipients from the United Network for Organ Sharing database were identified (2010-2024) and stratified by MELD-XI score: low (≤9), intermediate (>9 to <13), and high (≥13) categories. Multivariate logistic regression and Cox proportional hazard models were applied to determine associations between MELD-XI score and postoperative outcomes. Results: Among 30,148 lung transplant recipients, 90.6% had low, 6.9% intermediate, and 2.5% high MELD-XI scores at time of transplant listing. Greater MELD-XI score was associated with significantly increased mortality at 30-day, 90-day, 1-year, 5-year, and 10-year time points ( Conclusions: Preoperative MELD-XI scores >9 independently predicted greater posttransplant mortality and major complications. Incorporating MELD-XI into lung transplant candidate assessments can improve risk stratification and inform perioperative planning.
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