Evidence map›Paper›PMID 41960101›Full record

ArticleJTCVS open2026

Impact of hypoplastic left heart syndrome anatomic subtype on mortality, ventricular function, and atrioventricular valve function in the current era.

Elizabeth M Cordoves, Gerardo Ramos-Lemos, Vincent R LaSala, Halil Beqaj, Paul Trackey, Chunhui Wang, Andrew B Goldstone, Paul A Kurlansky, Stephanie Levasseur, Amee Shah and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JTCVS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elizabeth M CordovesDivision of Cardiac, Thoracic, and Vascular Surgery, Section of Congenital and Pediatric Cardiac Surgery, NY-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY.
Gerardo Ramos-LemosDivision of Cardiac, Thoracic, and Vascular Surgery, Section of Congenital and Pediatric Cardiac Surgery, NY-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY.
Vincent R LaSalaDivision of Cardiac, Thoracic, and Vascular Surgery, Section of Congenital and Pediatric Cardiac Surgery, NY-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY.
Halil BeqajDivision of Cardiac, Thoracic, and Vascular Surgery, Section of Congenital and Pediatric Cardiac Surgery, NY-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY.
Paul TrackeyDivision of Cardiac, Thoracic, and Vascular Surgery, Section of Congenital and Pediatric Cardiac Surgery, NY-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY.
Chunhui WangDivision of Cardiothoracic and Vascular Surgery, New York Presbyterian Hospital/Columbia University Irving Medical Center, New York, NY.
Andrew B GoldstoneDivision of Cardiac, Thoracic, and Vascular Surgery, Section of Congenital and Pediatric Cardiac Surgery, NY-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY.
Paul A KurlanskyDivision of Cardiothoracic and Vascular Surgery, New York Presbyterian Hospital/Columbia University Irving Medical Center, New York, NY.
Stephanie LevasseurDivision of Pediatric Cardiology, Department of Pediatrics, NY-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY.
Amee ShahDivision of Pediatric Cardiology, Department of Pediatrics, NY-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY.
Ganga KrishnamurthyDivision of Neonatology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY.
Emile BachaDivision of Cardiac, Thoracic, and Vascular Surgery, Section of Congenital and Pediatric Cardiac Surgery, NY-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY.
David KalfaDivision of Cardiac, Thoracic, and Vascular Surgery, Section of Congenital and Pediatric Cardiac Surgery, NY-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The aortic atresia/mitral stenosis (AA/MS) subtype in hypoplastic left heart syndrome (HLHS) has been associated with poor single-ventricle palliation outcomes. We evaluated whether HLHS anatomic subtype influences transplant and Fontan-takedown-free survival and right ventricular (RV) and tricuspid valve (TV) function in the current era. Methods: Retrospective chart review was done for 219 consecutive neonates with HLHS who received a Norwood at our center (2006-2023). Primary outcomes were freedom from mortality/transplant/Fontan takedown post-Norwood (n = 219) and Fontan (n = 133). Moderate or greater RV dysfunction and TV failure were secondary outcomes. Log-rank and Cox regression evaluated primary outcomes; Fine-Gray model assessed secondary outcomes. Results: Post-Norwood (n = 219), we found that AA/MS was not associated with mortality/transplant/Fontan takedown (log-rank and Cox Conclusions: No association was observed between AA/MS and reduced transplant/takedown-free survival, RV function, or TV failure. Aortic stenosis was associated with increased risk of moderate or greater RV dysfunction post-Fontan. We found that preoperative RV and TV dysfunction, genetic syndrome, and extracardiac anomalies remain risk factors.

Indexed as

aortic atresiahypoplastic left heart syndromemitral stenosisright ventricular functiontricuspid valve failure

Identifiers

PMID41960101
PMCPMC13059910

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.