ArticleJTCVS open2026
Myocardial protection by adenosine triphosphate-sensitive potassium channel opener diazoxide involves sulfonylurea receptor 2 subunit.
Article in JTCVS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Lessons learned from 100 failed mouse Langendorff experiments.JTCVS open · 2026Article
- Potassium channel-targeted therapy in reducing vascular complications in diabetes mellitus: novel insights.Frontiers in pharmacology · 2026Review
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Objective: Pharmacologic openers of adenosine triphosphate-sensitive potassium (K Methods: Mice lacking SUR2 (knockout) and wild-type litter mates (genotype confirmed) were randomly assigned to 90 minutes of global ischemia in a Langendorff model after hypothermic hyperkalemic cardioplegia with or without DZX (100 μM/L) (N = 9-14 per group). Left ventricular developed pressure, end-diastolic pressure, and coronary flow were compared before and after global ischemia. Data acquisition and interpretation were blinded. Results: Prolonged global ischemia with cardioplegia was associated with reduced left ventricular developed pressure and increased end-diastolic pressure that was prevented by DZX in wild-type but not SUR2 knockout hearts, consistent with DZX cardioprotection being mediated by a K Conclusions: Cardioprotection provided by DZX was lost with genetic deletion of SUR2, implicating SUR2 as a subunit of a cardioprotective K
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