Evidence map›Paper›PMID 41960063›Full record

ArticleJTCVS open2026

In vivo growing leporine model of pulmonary artery banding induces inflammation and vascular remodeling via pathways conserved across species.

Danielle M Mullis, James Y Lee, Masafumi Shibata, Veronica Toro Arana, Sumanth Kidambi, Amit Sharir, Perry S Choi, Gentaro Ikeda, Riya Nilkant, Hiroyuki Takashima and 4 more

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In one paragraph

Article in JTCVS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Danielle M MullisDepartment of Cardiothoracic Surgery, Stanford University, Stanford, Calif.
James Y LeeDepartment of Cardiothoracic Surgery, Stanford University, Stanford, Calif.
Masafumi ShibataDepartment of Cardiothoracic Surgery, Stanford University, Stanford, Calif.
Veronica Toro AranaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, Calif.
Sumanth KidambiDepartment of Cardiothoracic Surgery, Stanford University, Stanford, Calif.
Amit SharirDepartment of Cardiothoracic Surgery, Stanford University, Stanford, Calif.
Perry S ChoiDepartment of Cardiothoracic Surgery, Stanford University, Stanford, Calif.
Gentaro IkedaDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, Calif.
Riya NilkantDepartment of Cardiothoracic Surgery, Stanford University, Stanford, Calif.
Hiroyuki TakashimaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, Calif.
Tsuyoshi UeyamaDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, Calif.
Jay A HuberDepartment of Cardiothoracic Surgery, Stanford University, Stanford, Calif.
Y Joseph WooDepartment of Cardiothoracic Surgery, Stanford University, Stanford, Calif.
Michael MaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, Calif.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Characterization of pulmonary artery banding in a growing leporine model with comparison to human tissue has yet to be published. We hypothesized that there would be inflammatory changes that occur to the myocardium despite small changes to the gradients across the pulmonary arteries in rabbits that underwent pulmonary artery banding. Additionally, we analyzed tissue from humans to determine whether these are pathways preserved across species. Methods: Female 2-month-old New Zealand white rabbits were anesthetized, and a band was placed loosely around the main pulmonary artery (n = 4). The rabbits underwent either echocardiographic or magnetic resonance imaging, and the hearts were harvested when the rabbits weighed approximately 3.9 kg. Right ventricle samples from humans (tissues that would have been discarded otherwise) were obtained for comparison. Results: The right ventricles of the rabbits that underwent pulmonary artery banding exhibit significantly more CD31+α-SMA+ expression than the control rabbits ( Conclusions: Even with minimal changes to the pulmonary artery gradient, growing leporine rabbits exhibit significant inflammation, vascular remodeling, and fibrosis in the right ventricle in response to pulmonary artery banding. These changes are conserved across species, because we found that the right ventricles of patients with pulmonary arterial hypertension or that had undergone pulmonary artery banding also exhibit similar expression of inflammation, vascular remodeling, and fibrosis.

Indexed as

bandinghumanpulmonary arteryrabbittricuspid valve

Identifiers

PMID41960063
PMCPMC13059996

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.