Evidence map›Paper›PMID 41960057›Full record

ArticleJTCVS open2026

Impact of age at Norwood surgery on pre-stage II outcomes in neonates with hypoplastic left heart syndrome.

Halil Beqaj, V Reed LaSala, Sophia Jackman, Paul Kurlansky, Edward Buratto, Priyanka Asrani, Michael Fremed, Andrew Goldstone, Oliver Barry, Sabrina Law and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JTCVS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Halil BeqajVagelos College of Physicians and Surgeons, Columbia University, New York, NY.
V Reed LaSalaDivision of Cardiac, Thoracic, and Vascular Surgery, Section of Pediatric and Congenital Cardiac Surgery, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Sophia JackmanVagelos College of Physicians and Surgeons, Columbia University, New York, NY.
Paul KurlanskyDivision of Cardiac, Thoracic, and Vascular Surgery, Section of Pediatric and Congenital Cardiac Surgery, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Edward BurattoDivision of Cardiac, Thoracic, and Vascular Surgery, Section of Pediatric and Congenital Cardiac Surgery, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Priyanka AsraniDivision of Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Michael FremedDivision of Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Andrew GoldstoneDivision of Cardiac, Thoracic, and Vascular Surgery, Section of Pediatric and Congenital Cardiac Surgery, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Oliver BarryDivision of Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Sabrina LawDivision of Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Diana Vargas ChavesDivision of Neonatology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Tarif ChoudhuryDivision of Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Stephanie LevasseurDivision of Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Ganga KrishnamurthyDivision of Neonatology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Christopher PetitDivision of Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Emile BachaDivision of Cardiac, Thoracic, and Vascular Surgery, Section of Pediatric and Congenital Cardiac Surgery, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
David KalfaCardiovascular Surgery, Heart institute, Nicklaus Children's Hospital, Department of Surgery and Pediatrics, Herbert Wertheim College of Medicine, Florida International University, Miami, Fla.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The timing of Norwood surgery, a potentially modifiable component of hypoplastic left heart syndrome management, lacks expert consensus, and its relationship to longer-term outcomes remains unclear. Methods: We performed a retrospective cohort study of neonates with hypoplastic left heart syndrome who underwent Norwood surgery between 2006 and 2023. The primary outcome was a composite of pre-stage II mortality or transplant and prolonged intensive care unit length of stay. The relationship between age at Norwood surgery and the composite outcome was assessed primarily through Cox proportional hazards analysis, modeling age as a restricted cubic spline, as a binary factor, and as a linear variable. Log-rank tests were used to compare subgroups based on age cutoffs determined from regression analysis. Results: In multivariable analysis with age modeled as restricted cubic spline, age at surgery (chi-square = 8.31, Conclusions: Age at Norwood surgery is independently associated with pre-stage II outcomes. Surgery between days 3 and 5 may represent an optimal window for intervention, with delays in surgery beyond this period being associated with increased risk of adverse outcomes.

Indexed as

HLHSmortalityNorwoodpre–stage IIprolonged ICU LOS

Identifiers

PMID41960057
PMCPMC13059855

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.