ArticleFrontiers in pediatrics2026
EBV-DNA viral load and lymphocyte subsets correlation in pediatric infectious mononucleosis with hepatic injury a retrospective cohort study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
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Abstract
Background: Infectious mononucleosis is often complicated by hepatic injury, in which Epstein-Barr virus load and immune response may play important roles. Objective: To investigate the correlation between EBV-DNA viral load and lymphocyte subsets in patients with IM with hepatic injury. Methods: A retrospective cohort study was conducted on children diagnosed with IM from January 2022 to August 2025. Patients were divided into hepatic injury group and non-hepatic injury group. EBV-DNA load, lymphocyte subsets (CD3+, CD4+, CD8+, CD19+, CD16+ CD56+) and liver function indicators were measured and analyzed. Results: Among 202 children, the hepatic injury group ( Conclusion: Elevated EBV-DNA load and an increased CD8+ T cell percentage are independently associated with hepatic injury in pediatric IM. Monitoring these parameters may help in identifying children at higher risk for hepatic involvement, although prospective validation is required.
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