Evidence map›Paper›PMID 41959947›Full record

Observational studyDepression and anxiety2026

Whole Blood Transcriptome Analysis in Female Adolescents With Depression Accompanied by Nonsuicidal Self-Injury and Suicide Attempt.

Zimo Zhou, Shuai Wang, Jiajun Yin, Zhenru Guo, Lianlian Yang, Xiaoshan Gao, Yu Xia, Yuanyuan Yang, Zhangyan Shan, Lin Tian

Abstract readObservational Study
In one paragraph

Observational study in Depression and anxiety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zimo ZhouThe Affiliated Mental Health Center of Jiangnan University, Wuxi, Jiangsu, China.ORCID https://orcid.org/0009-0009-7153-5145
Shuai WangThe Affiliated Mental Health Center of Jiangnan University, Wuxi, Jiangsu, China.
Jiajun YinThe Affiliated Mental Health Center of Jiangnan University, Wuxi, Jiangsu, China.ORCID https://orcid.org/0000-0001-6778-1524
Zhenru GuoThe Affiliated Mental Health Center of Jiangnan University, Wuxi, Jiangsu, China.ORCID https://orcid.org/0009-0007-6898-2169
Lianlian YangThe Affiliated Mental Health Center of Jiangnan University, Wuxi, Jiangsu, China.
Xiaoshan GaoSchool of Wuxi Medicine, Nanjing Medical University, Wuxi, Jiangsu, China, njmu.edu.cn.ORCID https://orcid.org/0009-0008-7420-9006
Yu XiaThe Affiliated Mental Health Center of Jiangnan University, Wuxi, Jiangsu, China.ORCID https://orcid.org/0009-0006-4763-976X
Yuanyuan YangThe Affiliated Mental Health Center of Jiangnan University, Wuxi, Jiangsu, China.ORCID https://orcid.org/0009-0007-3922-2160
Zhangyan ShanThe Affiliated Mental Health Center of Jiangnan University, Wuxi, Jiangsu, China.ORCID https://orcid.org/0009-0001-0110-5969
Lin TianThe Affiliated Mental Health Center of Jiangnan University, Wuxi, Jiangsu, China.ORCID https://orcid.org/0000-0003-0983-9278

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Study Objective: Using RNA sequencing (RNA-seq) on blood samples from depressed female adolescents with nonsuicidal self-injury (NSSI) or suicide attempt (SA), this study explored links between peripheral blood gene expression and these behaviors. Methods: Female adolescents with major depressive disorder (MDD) who were of the same age as the subjects were enrolled in the study and divided into three groups: MDD, NSSI, and NSSI + SA. Whole blood samples were collected for RNA-seq and bioinformatics analysis. Results: Multivariate linear regression analysis revealed that the NADH dehydrogenase iron-sulfur protein 7 ( Conclusion: This study revealed the whole-blood transcriptomic features of female adolescent MDD patients with different behavioral phenotypes. It found that neuroimmune responses, along with core genes Trial Registration: ClinicalTrials.gov identifier: ChiCTR2500107586.

Indexed as

Chemokine CXCL10Major Depressive DisorderSelf-Injurious BehaviorSuicide, AttemptedTranscriptomeAdolescentFemaleGene Expression ProfilingHumansChemokine CXCL10adolescentsdepressionnonsuicidal self-injuryRNA-seqsuicide attempttranscriptome analysis

Identifiers

PMID41959947
PMCPMC13058443

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.