ArticlePlastic and reconstructive surgery. Global open2026
Late-Onset Upper Eyelid Edema Following Temporal Hollow Correction With Hyaluronic Acid.
Article in Plastic and reconstructive surgery. Global open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyaluronic acid (HA) fillers are widely used for facial rejuvenation, offering favorable safety outcomes. Although early-onset complications such as lower eyelid edema and tear trough Tyndall effect are well documented, late-onset manifestations-particularly upper eyelid edema occurring more than 6 months postinjection-remain poorly understood and often misdiagnosed. We report the case of a 51-year-old woman who presented with isolated, persistent, bilateral upper eyelid swelling. Imaging and laboratory workup, including thyroid function tests and orbital magnetic resonance imaging, were unremarkable. Given the inconclusive findings, upper blepharoplasty was performed for both therapeutic and diagnostic purposes. Histopathologic analysis revealed dermal basophilic deposits consistent with HA, with no inflammatory reaction. Only after surgery did the patient recall undergoing temporal filler injections 2 years earlier. This case illustrated the resilience and migration potential of HA fillers-especially when injected into avascular gliding planes such as the temporal region-and the capacity for remote complications. Unlike other documented cases involving direct periorbital injection and successful hyaluronidase resolution, our case required surgical intervention due to delayed diagnosis. Clinicians must maintain a high index of suspicion for HA-related complications, even when symptoms manifest far from the typical injection site and long after the procedure. Thorough aesthetic history-taking is essential to avoid misdiagnoses such as thyroid orbitopathy or Melkersson-Rosenthal syndrome. To our knowledge, this is the first reported case of chronic upper eyelid edema secondary to temporal HA filler injection, and we advocate for greater awareness of this presentation within the aesthetic and ophthalmologic communities.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.