Evidence map›Paper›PMID 41959785›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Genome-Wide Discovery Reveals Adipose-Specific and Systemic Regulators of Insulin Resistance.

Mario Garcia-Urena, Pearlyn Jia Ying Toh, Raquel Sanz Martinez, Rama Kaalia, Mayank Murali, Hesam Dashti, Yaxin Jing, César Cunha, María Jose Romero-Lado, Yuejiao Huang and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mario Garcia-UrenaNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3376-9460
Pearlyn Jia Ying TohNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-0907-7947
Raquel Sanz MartinezNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0009-0000-4206-0229
Rama KaaliaNovo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-1305-0774
Mayank MuraliNovo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-7118-2698
Hesam DashtiNovo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Yaxin JingInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-1657-6931
César CunhaNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-3811-2932
María Jose Romero-LadoNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0009-0001-9500-3292
Yuejiao HuangGlobe Institute, University of Copenhagen, Copenhagen, Denmark.ORCID 0009-0003-0548-792X
Martin WabitschDivision of Pediatric Endocrinology and Diabetes, Ulm University Medical Center ,Ulm, Germany.ORCID 0000-0001-6795-8430
Melina ClaussnitzerNovo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-2450-736X
Tuomas O KilpeläinenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-8349-3028

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Bridging the gap between type 2 diabetes GWAS and therapeutic targetsUM1DK126185 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CLAUSSNITZER, MELINA C, GLOYN, ANNA LOUISE · 2020 to 2024
$9.5M
NIDDK NIH HHS P30 DK040561NIDDK NIH HHS UM1 DK126185
6 · The paper itself

Abstract

Insulin resistance (IR) is a key driver of cardiometabolic disease, yet its genetic and regulatory architecture remains incompletely understood. We performed a multi-trait GWAS of fasting insulin, triglycerides, and HDL cholesterol (n ≤ 1.25 million), identifying 282 IR-associated loci, including 70 novel. Polygenic score analyses linked IR to an adverse fat distribution characterized by reduced subcutaneous and increased visceral and ectopic fat. Stratifying loci by BMI associations revealed biologically distinct variant subgroups with divergent regulatory activity during adipogenesis. Enhancer-to-gene mapping implicated 72 loci in adipose-specific regulation, including a novel

Identifiers

PMID41959785
PMCPMC13060440

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.