Evidence map›Paper›PMID 41959736›Full record

ReviewGenes & diseases2026

Molecular mastery: Harnessing DNA technology for disease prevention.

Giri Rajasekhar Dornadula, Ramakrishna Chilakala, Sadak Basha Shaik, Pramod Kumar Meriga, Likhitha Chintha, Yeshwanth Gurugari, Kranthi Kumar D, Sameena Fatima Shaik, Sun Hee Cheong

Abstract readReview
In one paragraph

Review in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giri Rajasekhar DornadulaDepartment of Pharmacy Practice, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh 516126, India.
Ramakrishna ChilakalaDepartment of Marine Bio-Food Science, Chonnam National University, Yeosu 59626, Republic of Korea.
Sadak Basha ShaikCollege of Dentistry Department of Bio-clinical Sciences, Kuwait University 13110, Kuwait.
Pramod Kumar MerigaDepartment of Pharmacy Practice, Jawaharlal Nehru Technological University - OTPRI, Ananthapuramu, Andhra Pradesh 515001, India.
Likhitha ChinthaDepartment of Pharmacy Practice, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh 516126, India.
Yeshwanth GurugariDepartment of Pharmacy Practice, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh 516126, India.
Kranthi Kumar DDepartment of Pharmacy Practice, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh 516126, India.
Sameena Fatima ShaikDepartment of Biochemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh 517502, India.
Sun Hee CheongDepartment of Marine Bio-Food Science, Chonnam National University, Yeosu 59626, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advances in DNA technology are revolutionizing the landscape of illness prevention, providing new opportunities to combat hereditary abnormalities and chronic diseases before they manifest. CRISPR-Cas9 gene editing, epigenetic alterations, somatic cell genome editing, and RNA-based therapies are all significant advancements in this field. These techniques enable precise changes to DNA and gene expression, potentially preventing a wide range of illnesses at their genetic origins. The following discussion delves into the transformative potential of these technologies. CRISPR-Cas9 is notable for its precision in fixing defective genes, offering promise for avoiding diseases, such as cystic fibrosis and sickle cell anemia. Epigenetic modifications caused by environmental factors are also opening up new avenues for preventing chronic illnesses and malignancies. Furthermore, somatic cell genome editing is a potential, ethically viable strategy as it targets non-reproductive cells, preventing heritable genetic alterations. Along with these developments, RNA-based therapies are emerging as a new avenue for disease prevention. This paper will explore each of these advancements, their applications, and the ethical and technical challenges involved.

Indexed as

CRISPR-Cas9gene editingDefective genesEpigenetic alterationsRNA-based therapiesSomatic cell genome editing

Identifiers

PMID41959736
PMCPMC13058969

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.