ArticleFrontiers in aging neuroscience2026
Corneal epithelial thickness can reflect the stage of Parkinson's disease and the severity of dry eye.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To systematically analyze corneal epithelial thickness (CET) distribution in Parkinson's disease (PD) using anterior segment optical coherence tomography (AS-OCT) and investigate its correlation with disease stage and dry eye severity. Methods: This cross-sectional study enrolled 60 PD patients (120 eyes) and 29 age- and sex-matched healthy controls (58 eyes). The accessed parameters included dry eye disease (DED) metrics, such as the Ocular Surface Disease Index (OSDI), Schirmer I test (sIt), tear breakup time (BUT), corneal fluorescein staining (CFS), corneal sensitivity, and zonal CET measured by AS-OCT in central 2-mm, 5-mm, and 6-mm zones. Baseline PD characteristics included disease duration, levodopa equivalent daily dose (LEDD), Hoehn and Yahr (H-Y) stage, Movement Disorder Society Unified Parkinsond dPisease Rating Scale (MDS-UPDRS Part III), and Montreal Cognitive Assessment (MoCA). Results: PD patients showed significantly higher OSDI and CFS ( Conclusion: This study demonstrates, for the first time, that CET correlates with both dry eye severity and H-Y stage in PD. AS-OCT-based CET mapping may serve as a non-invasive biomarker for early neurodegeneration detection and guide ocular surface management.
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