ArticleFrontiers in cellular and infection microbiology2026
Host-directed microRNA-based intervention against intracellular
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Design of a cyclic peptide targeting intracellular Staphylococcus aureus.Molecular biomedicine · 2026Article
- Fighting the invader: strategies against intracellular bacteria.Frontiers in pharmacology · 2026Review
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Authors and funding
10 authors.
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Abstract
Background: The intracellular persistence of Methods: We performed a high-throughput screen of 2,469 human miRNA mimics in A549 epithelial cells infected with Results: From this screen, ten candidates were identified, of which miR-4430, miR-1249-5p, and miR-147a consistently reduced intracellular bacterial burden and protected host cells. Transcriptomic analysis revealed complementary pathway-level programs: miR-4430 enhanced innate immune pathways, including STAT1- and PTAFR-associated signalling programs, while miR-1249-5p and miR-147a modulated extracellular matrix organisation and integrin-mediated adhesion, thereby interfering with bacterial entry. Discussion: These findings highlight a coordinated host defence strategy in which miR-4430 calibrates immune responses, while miR-1249-5p and miR-147a remodel host adhesion machinery. Together, they elicit complementary pressures that transiently reduce
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