Evidence map›Paper›PMID 41959553›Full record

ArticleBioactive materials2026

Reconstructing the ischemic osteogenic microenvironment through hierarchical scaffolds orchestrating Mg

Zijie Pei, Haojing Xu, Piqian Zhao, Ya Wen, Ze Zhang, Liangkun Huang, Mengyu Wang, Bo Peng, Liangyuan Wen, Peng Wen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zijie PeiDepartment of Orthopedics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China.
Haojing XuState Key Laboratory of Clean and Efficient Turbomachinery Power Equipment, Department of Mechanical Engineering, Tsinghua University, China.
Piqian ZhaoDepartment of Orthopedics, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, China.
Ya WenCapital Medical University School of Biomedical Engineering, China.
Ze ZhangDepartment of Orthopedics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China.
Liangkun HuangDepartment of Orthopedics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China.
Mengyu WangDepartment of Orthopedics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China.
Bo PengState Key Laboratory of Clean and Efficient Turbomachinery Power Equipment, Department of Mechanical Engineering, Tsinghua University, China.
Liangyuan WenDepartment of Orthopedics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China.
Peng WenState Key Laboratory of Clean and Efficient Turbomachinery Power Equipment, Department of Mechanical Engineering, Tsinghua University, China.
Fengpo SunDepartment of Orthopedics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic bone defects remain a major challenge in bone tissue engineering, primarily due to insufficient angiogenesis caused by severely compromised local blood supply. Here, we develop a bioactive implant that mechanistically amplifies magnesium-induced angiogenesis by integrating pro-angiogenic liposomes encapsulating neuropilin-1 (NRP-1) with a 3D-printed magnesium (Mg) alloy porous scaffold. The customized Mg scaffold matched defect morphology, provided reliable mechanical support, and featured interconnected micropores to facilitate bone ingrowth and integration. Composite surface coatings simultaneously moderated the rapid degradation of Mg and supplied abundant binding sites for NRP-1-loaded lipos, enabling coordinated regulation of angiogenesis and osteogenesis. In an ischemic bone defect model, the scaffold significantly enhanced neovascularization, bone formation density, and interfacial osseointegration. Mechanistically, the controlled release of Mg

Indexed as

AngiogenesisIschemic bone defectMagnesium scaffoldNeuropilin-1Osteogenesis

Identifiers

PMID41959553
PMCPMC13059125

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.