Evidence map›Paper›PMID 41959552›Full record

ArticleBioactive materials2026

Immune-activating PTL/nanowire composite coating on Ti surface enables macrophage-driven bacterial clearance and osseointegration.

Ruiyue Hang, Huanming Chen, Liwei Yang, Ruoyu Di, Yuyu Zhao, Runhua Yao, Xiaohong Yao, Huaiyu Wang, Yin Xiao, Ruiqiang Hang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruiyue HangShanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.
Huanming ChenShanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.
Liwei YangShanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.
Ruoyu DiShanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.
Yuyu ZhaoShanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.
Runhua YaoShanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.
Xiaohong YaoShanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.
Huaiyu WangCenter for Human Tissues and Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.
Yin XiaoSchool of Medicine and Dentistry, Institute for Biomedicine and Glycomics, Griffith University, Gold Coast, Queensland, Australia.
Ruiqiang HangShanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implant-associated infections and loosening remain formidable clinical challenges. Conventional strategies such as incorporating antibiotics and metal ions can result in drug resistance and systemic toxicity, ultimately compromising tissue regeneration. Herein, we propose an immune-driven strategy for safe and effective anti-infection and pro-osseointegration, in which early immune activation promotes bacterial clearance, followed by timely resolution of inflammation to support angiogenesis and osteogenesis. As proof of the principle, gradient phase-transited lysozyme (PTL) on fixed size sodium titanate nanowires (PTL/nanowire composite coating) was constructed on Ti surface, creating a multifunctional platform for high-throughput screening (HTS) of optimal PTL dosages to support macrophage-driven bacterial clearance and osseointegration. The results revealed that PTL markedly enhanced bacterial clearance of macrophages (MΦs) through activating their Toll-like receptor 4 (TLR4) signaling pathway, while the nanowires beneath the PTL could promptly convert MΦs into pro-healing M2 phenotype, creating favorable macrophage-mediated immune microenvironment that promoted angiogenesis and osteogenesis. Among the tested formulations, moderate PTL dosage (PTL-3) achieved optimal balance of bacterial clearance and bone regeneration.

Indexed as

AntibiosisHigh-throughput screeningOsseointegrationPhase-transited lysozymeTitanium implant

Identifiers

PMID41959552
PMCPMC13059000

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.