Evidence map›Paper›PMID 41959508›Full record

ArticlebioRxiv : the preprint server for biology2026

SUMO mediates the coordinate regulation of meiotic chromosome length and crossover rate.

Yan Yun, Huanyu Qiao, Martin White, Sumit Sandhu, Wendy Qiu, Sarah Bourne, Anusha Deshpande, Shubhang Bhatt, Ajay Sharma, Logan Bailey and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yan YunHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.
Huanyu QiaoHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.
Martin WhiteDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.
Sumit SandhuHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.
Wendy QiuHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.
Sarah BourneHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.
Anusha DeshpandeHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.
Shubhang BhattHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.
Ajay SharmaHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.
Logan BaileyHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.
Hung TranHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.
Ben VanHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.
H B D Prasada RaoHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.
Neil HunterHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0003-1498-2327

Funding

Roles of BRCA2 in Mammalian Meiosis and Gamete QualityR01HD109322 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NEIL HUNTER, Wolf-Dietrich Heyer · 2024 to 2026
$2.0M
Environmental Health Perspectives, NIEHS27302C0031 · NIEHS · 2008 to 2008
$1.2M
NICHD NIH HHS R01 HD109322NIEHS NIH HHS 27302C0031
6 · The paper itself

Abstract

Meiotic prophase-I chromosomes are organized into linear arrays of chromatin loops anchored to proteinaceous axes that define the interaction interfaces for the pairing and synapsis of homologous chromosomes. Chromatin loop size and axial chromosome length are inversely correlated and vary widely both between and within species, including between the sexes. The molecular basis of this variation remains unclear. Here, we provide evidence that the small ubiquitin-like modifier, SUMO, regulates loop-axis organization in mouse meiosis. Our analysis shows that the longer axes of oocyte chromosomes contain more SUMO per unit length than the shorter axes of spermatocyte chromosomes. In mouse models, the loss of SUMO1 results in shorter axes and longer chromatin loops. Conversely, increased SUMO1 conjugation, caused by mutation of the SENP1 isopeptidase, produces longer axes with shorter loops. Axis length positively correlates with meiotic recombination. Accordingly,

Identifiers

PMID41959508
PMCPMC13060790

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.