Evidence map›Paper›PMID 41959507›Full record

ArticlebioRxiv : the preprint server for biology2026

Coupling between sterol and sphingolipid structure in ordered membrane domains.

Israel Juarez-Contreras, Hyesoo Kim, Itay Budin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Israel Juarez-ContrerasDepartment of Biochemistry & Molecular Biophysics, University of California San Diego, La Jolla, CA 92093, USA.
Hyesoo KimDepartment of Biochemistry & Molecular Biophysics, University of California San Diego, La Jolla, CA 92093, USA.
Itay BudinDepartment of Biochemistry & Molecular Biophysics, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-9706-4294

Funding

MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008326 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIVES, ELIZABETH A. · 1989 to 2020
$7.5M
Lipidic drivers of organelle function and dysregulationR35GM142960 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Itay Budin · 2021 to 2026
$4.3M
NIGMS NIH HHS R35 GM142960NIGMS NIH HHS T32 GM008326
6 · The paper itself

Abstract

A hallmark of eukaryotic membranes is the pairing of lineage-specific sterols with characteristic sphingolipid species. Mammalian cell membranes are enriched in both cholesterol and long-chain sphingolipids like sphingomyelin, whereas fungi synthesize ergosterol and very long-chain sphingolipids with sugar-containing head groups. It has been proposed that these two lipid classes co-evolved to support membrane structure and organization. Here we investigated how sterol structure and sphingolipid chain length together control membrane order and phase behavior. In the yeast

Identifiers

PMID41959507
PMCPMC13060081

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.