Evidence map›Paper›PMID 41959505›Full record

ArticlebioRxiv : the preprint server for biology2026

A sequence motif for DNA double-strand break and telomere healing during programmed DNA elimination.

Jansirani Srinivasan, Marro Agbaga, Vincent Terta, Brandon Estrem, James R Simmons, Ryan Oldridge, Mehwish Iftikhar, Abigail West, Hannah Lam, Thomas C Dockendorff and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jansirani SrinivasanDepartment of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN.
Marro AgbagaDepartment of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN.
Vincent TertaDepartment of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN.
Brandon EstremDepartment of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN.
James R SimmonsDepartment of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN.
Ryan OldridgeDepartment of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN.
Mehwish IftikharDepartment of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN.
Abigail WestDepartment of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN.
Hannah LamDepartment of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN.
Thomas C DockendorffDepartment of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN.
Jianbin WangDepartment of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN.ORCID 0000-0003-3155-894X

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Programmed DNA Elimination in Parasitic NematodesR01AI155588 · NIAID · UNIVERSITY OF TENNESSEE KNOXVILLE · PI Jianbin Wang · 2020 to 2026
$3.0M
A genetic model for metazoan programmed DNA eliminationR01GM151551 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI Jianbin Wang · 2023 to 2026
$1.2M
NIAID NIH HHS R01 AI155588NIGMS NIH HHS R01 GM151551NIH HHS P40 OD010440
6 · The paper itself

Abstract

Programmed DNA Elimination (PDE) is an exception to the paradigm of genome integrity, removing selected DNA sequences during development. PDE is observed in dozens of metazoan species from diverse phyla, but its molecular mechanisms and biological significance in most metazoa remain largely unknown. During PDE in the nematode

Indexed as

CRISPRDNA double-strand break (DSB)karyotypenematodeneotelomere formationOscheius tipulaeProgrammed DNA elimination (PDE)sequence for elimination (SFE)

Identifiers

PMID41959505
PMCPMC13060919

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.