ArticlebioRxiv : the preprint server for biology2026
FUNCTIONAL CONNECTIVITY ALTERATIONS IN MAJOR DEPRESSIVE DISORDER.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Major depressive disorder (MDD) is associated with brain-wide network disruptions. This study investigates a large resting-state functional magnetic resonance imaging dataset (N = 519) to analyze static and dynamic functional network connectivity (FNC). Using independent component analysis, our analysis revealed hyperconnectivity within sensorimotor and temporal subdomains, hypoconnectivity from higher cognitive networks, and hyperconnectivity from the default mode and sensorimotor domains in MDD. A novel frequency-sensitive dynamic approach identified disruptions in the temporal synchrony of brain states engaging the default mode-paralimbic, sensorimotor, and frontal regions, as well as the subcortical limbic, frontal, and salience regions. Overall, the findings highlight the utility of combining static and dynamic approaches in large neuroimaging datasets to elucidate the neural underpinnings of MDD pathology.
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