Evidence map›Paper›PMID 41959477›Full record

ArticlebioRxiv : the preprint server for biology2026

Genome-scale mapping of variant, enhancer and gene function in primary human CD4+ T cells.

Dewi P I Moonen, Annique Claringbould, Andreas R Gschwind, Stefan Schrod, Jana Braunger, Claudia Feng, Benedikt Rauscher, Jia Yi, Shirley Z Bi, Yves Matthess and 10 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Dewi P I MoonenEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit; Heidelberg, Germany.ORCID 0000-0002-7113-698X
Annique ClaringbouldOpen Targets, Wellcome Genome Campus; Hinxton, UK.ORCID 0000-0002-9201-6557
Andreas R GschwindDepartment of Genetics, Stanford University School of Medicine; Stanford, CA, USA.ORCID 0000-0002-0769-6907
Stefan SchrodEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit; Heidelberg, Germany.ORCID 0000-0001-9936-3984
Jana BraungerCentre for Organismal Studies, Heidelberg University; Heidelberg, Germany.ORCID 0000-0003-0820-9987
Claudia FengWellcome Sanger Institute, Wellcome Genome Campus; Hinxton, UK.ORCID 0000-0001-5912-1526
Benedikt RauscherEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit; Heidelberg, Germany.ORCID 0000-0002-1627-532X
Jia YiEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit; Heidelberg, Germany.ORCID 0000-0003-4795-471X
Shirley Z BiDepartment of Genetics, Stanford University School of Medicine; Stanford, CA, USA.
Yves MatthessInstitute of Biochemistry II, Goethe University Frankfurt; Frankfurt, Germany.ORCID 0000-0003-4040-1258
Manuel KaulichInstitute of Biochemistry II, Goethe University Frankfurt; Frankfurt, Germany.ORCID 0000-0002-9528-8822
Ricelle A AcobWaters Biosciences; Milpitas, CA, USA.ORCID 0009-0005-2039-7361
Aruna AyerWaters Biosciences; Milpitas, CA, USA.ORCID 0009-0004-2046-3990
Jesse M EngreitzDepartment of Genetics, Stanford University School of Medicine; Stanford, CA, USA.ORCID 0000-0002-5754-1719
Britta VeltenCentre for Organismal Studies, Heidelberg University; Heidelberg, Germany.ORCID 0000-0002-8397-3515
Oliver StegleEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit; Heidelberg, Germany.ORCID 0000-0002-8818-7193
Gosia TrynkaOpen Targets, Wellcome Genome Campus; Hinxton, UK.ORCID 0000-0002-6955-9529
Judith B ZauggEuropean Molecular Biology Laboratory (EMBL), Molecular Systems Biology Unit; Heidelberg, Germany.ORCID 0000-0001-8324-4040
Daniel SchraivogelEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit; Heidelberg, Germany.ORCID 0000-0002-5734-6980
Lars M SteinmetzEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit; Heidelberg, Germany.ORCID 0000-0002-3962-2865

Funding

Stanford Center for Connecting DNA Variants to Function and PhenotypeUM1HG011972 · NHGRI · STANFORD UNIVERSITY · PI JESSE M ENGREITZ, THOMAS QUERTERMOUS · 2021 to 2026
$10.5M
Function-based exploration of genetic variation at genome-scaleR01HG011664 · NHGRI · STANFORD UNIVERSITY · PI STEINMETZ, LARS M · 2022 to 2025
$2.9M
NHGRI NIH HHS R01 HG011664NHGRI NIH HHS UM1 HG011972
6 · The paper itself

Abstract

CD4+ T cells harbor a disproportionate enrichment of immune disease risk loci and represent the primary cellular context for immune disease biology, yet the genes and regulatory programs these variants affect remain largely unknown. We combined targeted Perturb-seq of 1,032

Identifiers

PMID41959477
PMCPMC13060838

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.