ArticlebioRxiv : the preprint server for biology2026
Cued unpredictable intermittent access exacerbates loss of control over ethanol drinking.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Loss of control over drinking is a hallmark feature of alcohol use disorder (AUD) that is modeled preclinically through escalation of ethanol consumption and aversion-resistant drinking. Prior work with other reinforcers suggests that within-session unpredictable, intermittent access (uIntA) promotes these phenotypes. However, the effect of uIntA on voluntary ethanol consumption is unknown. Methods: Male and female Long-Evans rats ( Results: Rats drinking under ContA and uIntA exhibited similar levels of average daily ethanol consumption at baseline. However, uIntA elicited a more robust dependence-induced escalation of ethanol consumption compared to ContA, with uIntA sustaining escalation through early withdrawal. Additionally, while rats with ContA to ethanol remained sensitive to quinine even after chronic ethanol vapor exposure, uIntA promoted aversion-resistant drinking in ethanol dependent rats. Conclusions: These results demonstrate that, compared to ContA, uIntA maintains ethanol drinking and exacerbates dependence-induced escalation and aversion-resistant ethanol consumption. This work positions uIntA as a powerful tool to assess psychological and neurobiological factors that may underlie loss of control over drinking.
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